Production and characterization of single-chain variable fragment antibodies targeting the breast cancer tumor marker nectin-4 [PDF]
Frontiers in Immunology, 2023 BackgroundNectin-4 is a novel biomarker overexpressed in various types of cancer, including breast cancer, in which it has been associated with poor prognosis.
Ching-Hsuan Liu +15 more
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Laryngeal Squamous Cell Carcinoma Is Characterized by a Stronger Expression of Nectin-4 Compared to Nectin-2 [PDF]
Current Issues in Molecular BiologyNectin-2 and Nectin-4 are cell adhesion molecules associated with the progression of various cancers. The main goal of this pilot study was to evaluate the expression patterns of Nectin-2 and Nectin-4 in laryngeal squamous cell carcinoma (LSCC).
Matej Maršić +7 more
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Nectin-4 regulates cellular senescence-associated enlargement of cell size [PDF]
Scientific Reports, 2023 Cellular senescence is defined as irreversible growth arrest induced by various stress, such as DNA damage and oxidative stress. Senescent cells exhibit various characteristic morphological changes including enlarged morphology.
Ryoko Katasho +3 more
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Synthesis of a novel specific nectin-4 tumor-targeted peptide optical molecular probe and its preliminary study in lung cancer [PDF]
Scientific ReportsNectin-4/PVRL-4 is overexpressed in tumors, driving proliferation and invasion. It’s a key target for solid tumor therapy. Current tumor imaging methods are inadequate.
Ting Jiang +8 more
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Clinical application prospects of Nectin-4 in pan-cancer: an analysis based on the Trialtrove database [PDF]
Journal for ImmunoTherapy of CancerThis research analyzes the global landscape of clinical trials focusing on therapies targeting the Nectin cell adhesion molecule 4 (Nectin-4) across various malignancies, using data from the Trialtrove database.
Lei Li +7 more
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Exploring Nectin-4 as a potential diagnostic biomarker in endometrial adenocarcinoma [PDF]
BMC Women's HealthBackground This study explored Nectin-4 expression in endometrial adenocarcinoma and examined its relationship with tumor grade, hormone receptor status, p53 expression, and mismatch repair (MMR) protein expression. Methods We retrospectively analyzed 55
Melike Ordu, Serife Ozlem Genc
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Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects [PDF]
BreastNectin-4 is a cell adhesion molecule which has gained more and more attention as a therapeutic target in cancer recently. Overexpression of Nectin-4 has been observed in various tumors, including breast cancer, and is associated with tumor progression ...
Yufei Wang +5 more
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An Analysis of Nectin-4 (PVRL4) in Penile Squamous Cell Carcinoma [PDF]
European Urology Open Science, 2023 Penile squamous cell carcinoma (PSCC) remains a worldwide healthcare concern with poor outcomes and inadequate therapeutic options. Molecular characterization continues to describe the intricacies of PSCC biology, which vary by human papillomavirus (HPV)
G.Daniel Grass +6 more
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Prognostic value of nectin-4 in human cancers: A meta-analysis [PDF]
Frontiers in Oncology, 2023 BackgroundMany reports have described that abnormal nectin-4 expression may be used as a prognostic marker in many tumors. However, these studies failed to reach a consensus.
Rongqiang Liu +6 more
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NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors [PDF]
Frontiers in ImmunologyIntroductionT cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of cytokines.
Cheng Wei +17 more
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