Results 21 to 30 of about 8,807 (99)

A humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer [PDF]

Journal of Nanobiotechnology
Background Gastric cancer represents a highly lethal malignancy with an elevated mortality rate among cancer patients, coupled with a suboptimal postoperative survival prognosis. Nectin-4, an overexpressed oncological target for various cancers, has been
Yue Wu, Min Zhu, Baihe Sun, Yongting Chen, Yuping Huang, Junwei Gai, Guanghui Li, Yanfei Li, Yakun Wan, Linlin Ma   +9 more
doaj   +2 more sources

A Case of Upper Tract Urothelial Carcinoma With Neuroendocrine Differentiation Successfully Treated With Enfortumab Vedotin and Pembrolizumab

IJU Case Reports
Introduction Upper tract urothelial carcinoma with neuroendocrine differentiation (UC‐NE) is extremely rare and generally associated with aggressive behavior and poor prognosis. Optimal treatment strategies remain unclear, particularly regarding the role
Kosei Taniguchi, Mamoru Hashimoto, Takahito Nakayama, Saizo Fujimoto, Shingo Toyoda, Takashi Kikuchi, Marco Antonio De Velasco, Osamu Maenishi, Takafumi Minami, Kazutoshi Fujita   +9 more
doaj   +2 more sources

Expression of Nectin-4 and Trop-2 in upper tract urothelial carcinoma: implications for biomarker-driven antibody-drug conjugate therapy. [PDF]

J Pathol Clin Res
Abstract Recent advancements in antibody‐drug conjugates, including FDA‐approved therapies targeting Nectin‐4 and Trop‐2, have transformed the cancer treatment landscape, including upper tract urothelial carcinoma (UTUC). However, varied treatment effects and drug‐associated adverse effects raise the question of whether patients should be selected ...
Shi P, Wu Q, Zhang Y, Chen T, Warrick JI, DeGraff DJ, Raman JD, Chen G.   +7 more
europepmc   +2 more sources

Expression of nectin-4 in papillary renal cell carcinoma

Discover Oncology, 2022
Background Nectin-4 contributes to tumor proliferation, lymphangiogenesis and angiogenesis in malignant tumors and is an emerging target in tumor therapy.
Stefanie Zschäbitz, Marie Mikuteit, Christine Stöhr, Edwin Herrmann, Iris Polifka, Abbas Agaimy, Lutz Trojan, Philipp Ströbel, Frank Becker, Christian Wülfing, Peter Barth, Michael Stöckle, Michael Staehler, Christian Stief, Axel Haferkamp, Markus Hohenfellner, Stefan Duensing, Stephan Macher-Göppinger, Bernd Wullich, Joachim Noldus, Walburgis Brenner, Frederik C. Roos, Bernhard Walter, Wolfgang Otto, Maximilian Burger, Andres Jan Schrader, Arndt Hartmann, Franziska Erlmeier, Sandra Steffens   +28 more
doaj   +1 more source

Gene expression of Nectin‐4 and its clinical significance in dogs with primary lung adenocarcinoma

Veterinary Medicine and Science, 2022
Background Canine primary lung adenocarcinoma (CPLA) is suspected by radiography or computed tomography; however, since there are no tumour markers, early diagnosis is difficult, and the prognosis is poor due to increased tumour volume. Nectin‐4 has been
Kei Tamura, Kumiko Ishigaki, Orie Yoshida, Terai Kazuyuki, Naoki Sakurai, Tatsuya Heishima, Tomoko Fujiyuki, Chieko Kai, Kazushi Asano   +8 more
doaj   +1 more source

Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation

Scientific Reports, 2021
Nectin-4, upregulated in various cancer cells, cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, p95-ErbB2 and ErbB2∆Ex16, enhancing DNA synthesis through the PI3K-AKT signaling in human breast cancer T47D cells in an adherent ...
Shin Kedashiro, Takeshi Kameyama, Kiyohito Mizutani, Yoshimi Takai   +3 more
doaj   +1 more source

Nectin-4 promotes osteosarcoma progression and metastasis through activating PI3K/AKT/NF-κB signaling by down-regulation of miR-520c-3p

Cancer Cell International, 2022
Purpose Nectin-4 is specifically up-regulated in various tumors, exert crucial effects on tumor occurrence and development. Nevertheless, the role and molecular mechanism of Nectin-4 in osteosarcoma (OS) are rarely studied.
Yongheng Liu, Guanghao Li, Yan Zhang, Lili Li, Yanting Zhang, Xiaoyu Huang, Xianfu Wei, Peng Zhou, Ming Liu, Gang zhao, Jinyan Feng, Guowen Wang   +11 more
doaj   +1 more source

Increased levels of nectin-4 as a serological marker for pre-eclampsia

Fujita Medical Journal, 2023
Objectives: Nectin-4 is a cell adhesion molecule with vital functions at adherens and tight junctions. Cumulative evidence now indicates that the NECTIN4 gene is overexpressed in a variety of cancers, and that the nectin-4 protein is both a disease ...
Hikari Yoshizawa, Haruki Nishizawa, Mayuko Ito, Akiko Ohwaki, Yoshiko Sakabe, Takao Sekiya, Takuma Fujii, Hiroki Kurahashi   +7 more
doaj   +1 more source

Nectin-4 Expression Is an Independent Prognostic Biomarker and Associated With Better Survival in Triple-Negative Breast Cancer

Frontiers in Medicine, 2019
Background: Triple-negative breast cancer (TNBC) represents about 10-20% of all invasive breast cancers and is associated with a poor prognosis. The nectin cell adhesion protein 4 (Nectin-4) is a junction protein involved in the formation and maintenance
Jasmin Zeindler, Savas Deniz Soysal, Savas Deniz Soysal, Salvatore Piscuoglio, Salvatore Piscuoglio, Charlotte K. Y. Ng, Robert Mechera, Robert Mechera, Andrej Isaak, Walter Paul Weber, Simone Muenst, Simone Muenst, Christian Kurzeder, Christian Kurzeder   +13 more
doaj   +1 more source

Nectin-4 significance in malignant neoplasms of the female reproductive system: a review of current data

Акушерство, гинекология и репродукция, 2020
Introduction. Nectin-4, a cell adhesion molecule of the immunoglobulin superfamily (IgSF), has been extensively studied in oncological diseases. Nectin-4 is involved in the formation of intercellular connections and promotes tumor cell proliferation ...
E. G. Romanov, K. A. Kokurina, A. A. Fedotova, Zh.E.A.K. Massolu, A. I. Andreeva, T. S. Khristoforova, R. A. Ivanova, K. V. Tarasova, M. A. Ivanov, A. E. Klyukina, M. A. Sharafan, E. V. Medvedko, M. P. Modenova   +12 more
doaj   +1 more source