Results 61 to 70 of about 8,807 (99)

Development of new therapy for canine mammary cancer with recombinant measles virus

Molecular Therapy: Oncolytics, 2016
Oncolytic virotherapy is a promising treatment strategy for cancer. We previously generated a recombinant measles virus (rMV-SLAMblind) that selectively uses a poliovirus receptor-related 4 (PVRL4/Nectin4) receptor, but not signaling lymphocyte ...
Koichiro Shoji, Misako Yoneda, Tomoko Fujiyuki, Yosuke Amagai, Akane Tanaka, Akira Matsuda, Kikumi Ogihara, Yuko Naya, Fusako Ikeda, Hiroshi Matsuda, Hiroki Sato, Chieko Kai   +11 more
doaj   +1 more source

Localization of Puncta Adherentia Junctions at GABAergic Synapses on Parvalbumin‐Positive GABAergic Inhibitory Neurons in the Mouse Hippocampus

Journal of Comparative Neurology, Volume 534, Issue 3, March 2026.
Puncta adherentia junctions (PAJs) were observed not only at glutamatergic excitatory synapses on excitatory neurons (E→E synapses) but also at glutamatergic synapses on GABAergic inhibitory neurons (E→I synapses) and at GABAergic synapses on excitatory (I→E synapses) and inhibitory neurons (I→I synapses) in cultured mouse hippocampal neurons.
Kimitaka Katanazaka, Hajime Shiotani, Muneaki Miyata, Takeshi Kameyama, Shin Kedashiro, Ryouhei Komaki, Shota Nishii, Yutaro Kashiwagi, Yuka Sato, Shigeo Okabe, Norio Chihara, Riki Matsumoto, Kiyohito Mizutani, Yoshimi Takai   +13 more
wiley   +1 more source

Invasive Bladder Cancer With Peritoneal Invasion and Rectal Involvement Causing Rectal, Bilateral Ureteral, and Common Bile Duct Obstruction Without a Retroperitoneal Mass: A Case Report

IJU Case Reports, Volume 9, Issue 2, March 2026.
ABSTRACT Introduction Bladder cancer (BC) is rarely associated with common bile duct (CBD) obstruction. We report a case of BC with peritoneal invasion and rectal involvement complicated by bilateral ureteral and biliary obstruction. Case Presentation A 77‐year‐old man presented with abdominal pain.
Kazuto Imai, Norihiko Masuda, Tatsuya Hazama, Toshihide Hosomi, Keita Hanada, Takakazu Matsushita, Toshiya Akao   +6 more
wiley   +1 more source

Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
This study analyzed the stability of 480 proteins in human serum samples collected from 10 healthy donors and incubated at room temperature for 0–48 h. Antibody array profiling revealed significant time‐dependent degradation of 201 proteins. Subsequent physicochemical and functional enrichment analyses demonstrated that the degraded proteins were ...
Yanlin Wang, Min Lang, Wei Huang, Siwei Zhu, Yingqing Mao, Shuhong Luo, Hua Dong, Ruo‐Pan Huang   +7 more
wiley   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Bismuth Bicycles

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Discovery, evolution and potential future applications of bismuth bicycle molecules—a novel class of therapeutics with unique properties. ABSTRACT Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules.
Saan Voss, Amin Sagar, Arnaud Tiberghien, Richard J. L. Hughes, Liuhong Chen, Inmaculada Rioja, Mark Frigerio, Michael J. Skynner, David R. Spring   +8 more
wiley   +1 more source

Measles skin rash: Infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to the epidermis.

PLoS Pathogens, 2020
Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have ...
Brigitta M Laksono, Paola Fortugno, Bernadien M Nijmeijer, Rory D de Vries, Sonia Cordisco, Thijs Kuiken, Teunis B H Geijtenbeek, W Paul Duprex, Francesco Brancati, Rik L de Swart   +9 more
doaj   +1 more source

Predictive role of ABC transporters in the efficacy of enfortumab vedotin for urothelial carcinoma

BJUI Compass
Objective To evaluate the correlation between ATP‐binding cassette (ABC) transporter expression and therapeutic efficacy of enfortumab vedotin (EV), an antibody‐drug conjugate targeting Nectin‐4, in urothelial cancer, as only a few studies have been ...
Toshiki Kijima, Atsuko Takada‐Owada, Hiroki Shimoda, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Hironori Betsunoh, Masahiro Yashi, Kazuyuki Ishida, Takao Kamai   +9 more
doaj   +1 more source

Increased expression of ATP‐binding cassette transporters in enfortumab vedotin‐resistant urothelial cancer

IJU Case Reports
Introduction In addition to reduced nectin‐4 expression, the upregulation of ATP‐binding cassette transporters has been suggested as a potential mechanism of resistance to enfortumab vedotin.
Mariko Kotono, Toshiki Kijima, Atsuko Takada‐Owada, Naoya Okubo, Ryo Kurashina, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Kazuyuki Ishida, Takao Kamai   +9 more
doaj   +1 more source

Effects of pregnancy on breast cancer immunology: immune biomarker and TIL quantification

npj Breast Cancer
Breast cancer diagnosed during pregnancy (PrBC) is a rare occurrence but may become more prevalent as women nowadays tend to postpone childbearing until later in life.
Kristin Galas, Moritz Gleitsmann, Julia Rey, Christine Solbach, Isabell Witzel, Thomas Karn, Sabine Schmatloch, Christian Schem, Andreas Schneeweis, Bruno Sinn, Tanja Fehm, Carsten Denkert, Peter Fasching, Anne-Sophie Litmeyer, Frederik Marmé, Paul Jank, Volkmar Müller, Sabine Seiler, Elmar Stickeler, Olaf Ortmann, Marion van Mackelenbergh, Valentina Nekljudova, Johannes Holtschmidt, Sibylle Loibl   +23 more
doaj   +1 more source