Therapeutic prospects of nectin-4 in cancer: applications and value [PDF]
Frontiers in OncologyNectin-4 is a Ca2+-independent immunoglobulin-like protein that exhibits significantly elevated expression in malignant tumors while maintaining extremely low levels in healthy adult tissues.
Kaiyue Li +4 more
doaj +5 more sources
Expression of nectin-4 in papillary renal cell carcinoma [PDF]
Discover Oncology, 2022 Background Nectin-4 contributes to tumor proliferation, lymphangiogenesis and angiogenesis in malignant tumors and is an emerging target in tumor therapy.
Stefanie Zschäbitz +28 more
doaj +3 more sources
Production and characterization of single-chain variable fragment antibodies targeting the breast cancer tumor marker nectin-4 [PDF]
Frontiers in Immunology, 2023 BackgroundNectin-4 is a novel biomarker overexpressed in various types of cancer, including breast cancer, in which it has been associated with poor prognosis.
Ching-Hsuan Liu +15 more
doaj +2 more sources
Laryngeal Squamous Cell Carcinoma Is Characterized by a Stronger Expression of Nectin-4 Compared to Nectin-2 [PDF]
Current Issues in Molecular BiologyNectin-2 and Nectin-4 are cell adhesion molecules associated with the progression of various cancers. The main goal of this pilot study was to evaluate the expression patterns of Nectin-2 and Nectin-4 in laryngeal squamous cell carcinoma (LSCC).
Matej Maršić +7 more
doaj +2 more sources
The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma [PDF]
Folia Histochemica et Cytobiologica, 2011 To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4.
Pauline Athanassiadou +4 more
doaj +5 more sources
Nectin-4 regulates cellular senescence-associated enlargement of cell size [PDF]
Scientific Reports, 2023 Cellular senescence is defined as irreversible growth arrest induced by various stress, such as DNA damage and oxidative stress. Senescent cells exhibit various characteristic morphological changes including enlarged morphology.
Ryoko Katasho +3 more
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Nectin-4 is a new histological and serological tumor associated marker for breast cancer [PDF]
BMC Cancer, 2007 Introduction Breast cancer is a complex and heterogeneous disease at the molecular level. Evolution is difficult to predict according to classical histoclinical prognostic factors.
Sauvan Richard +18 more
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Synthesis of a novel specific nectin-4 tumor-targeted peptide optical molecular probe and its preliminary study in lung cancer [PDF]
Scientific ReportsNectin-4/PVRL-4 is overexpressed in tumors, driving proliferation and invasion. It’s a key target for solid tumor therapy. Current tumor imaging methods are inadequate.
Ting Jiang +8 more
doaj +2 more sources
Clinical application prospects of Nectin-4 in pan-cancer: an analysis based on the Trialtrove database [PDF]
Journal for ImmunoTherapy of CancerThis research analyzes the global landscape of clinical trials focusing on therapies targeting the Nectin cell adhesion molecule 4 (Nectin-4) across various malignancies, using data from the Trialtrove database.
Lei Li +7 more
doaj +2 more sources
Expression of Nectin‐4 and Trop‐2 in upper tract urothelial carcinoma: implications for biomarker‐driven antibody‐drug conjugate therapy [PDF]
The Journal of Pathology: Clinical ResearchRecent advancements in antibody‐drug conjugates, including FDA‐approved therapies targeting Nectin‐4 and Trop‐2, have transformed the cancer treatment landscape, including upper tract urothelial carcinoma (UTUC).
Ping Shi +7 more
doaj +2 more sources