Results 91 to 100 of about 10,275 (197)

Enfortumab vedotin plus pembrolizumab in treatment‐naïve metastatic urothelial carcinoma patients: An Austrian real‐world analysis

International Journal of Cancer, Volume 158, Issue 6, Page 1654-1665, 15 March 2026.
What's new? New antibody‐drug conjugates (ADCs) and immunotherapies have helped expand treatment options for urothelial carcinoma (UC). Clinical trials suggest that the ADC enfortumab vedotin (EV) and the immunotherapeutic agent pembrolizumab, when used in combination, are especially effective against UC.
Dora Niedersuess‐Beke, Karl Mayrhofer, Johanna Krauter, Johannes Franke, Dominic Vais, Maximillian Pallauf, David Kiesl, Ferdinand Luger, Jacob Pfuner, Angelika Terbuch, Thomas Bauernhofer, Jasmin Spielgelberg, Andreas Banner, Stefan Aufderklamm, Clemens Wiesinger, Susanne Schnabel, Simon Peter Gampenrieder, Josef Mühlmann, Sonia Vallet, Sabine Weibrecht, Franz Stoiber, Haleh Andalibi, Harun Fajkovic, Hossein Taghizadeh, Jan Miechowiecki, Roman Taedcke, Daniel Heintel, Shahrokh F. Shariat, Martin Pichler, Wolfgang Hilbe, Renate Pichler   +30 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, Volume 20, Issue 3, Page 823-837, March 2026.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development.

Frontiers in Cellular and Infection Microbiology, 2014
Interaction of Herpes Simplex Virus (HSV) glycoprotein D (gD) with the host cell surface during Chlamydia trachomatis/HSV co-infection stimulates chlamydiae to become persistent.
Jennifer Vanover Hall, Jennifer Vanover Hall, Jingru eSun, Jessica eSlade, Jessica eSlade, Jennifer eKintner, Marissa eBambino, Judy eWhittimore, Robert V. Schoborg, Robert V. Schoborg   +9 more
doaj   +1 more source

Spatial heterogeneity of antibody–drug conjugate targets in pancreatic ductal adenocarcinoma

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, with limited therapeutic options, few patients showing targetable molecular changes. New therapeutic strategies are necessary. Antibody–drug conjugates (ADCs) have emerged as alternative therapeutic strategies across various cancer types. Herein, we analyze the expression and spatial
Deema Sabtan, Marie‐Lisa Eich, Florian Loch, Julen Karl Pérez Zuschneid, Markus Möbs, Judith Böhme, Frederick Klauschen, David Horst, Mihnea P Dragomir, Gabriel Dernbach, Simon Schallenberg   +10 more
wiley   +1 more source

Development of new therapy for canine mammary cancer with recombinant measles virus

Molecular Therapy: Oncolytics, 2016
Oncolytic virotherapy is a promising treatment strategy for cancer. We previously generated a recombinant measles virus (rMV-SLAMblind) that selectively uses a poliovirus receptor-related 4 (PVRL4/Nectin4) receptor, but not signaling lymphocyte ...
Koichiro Shoji, Misako Yoneda, Tomoko Fujiyuki, Yosuke Amagai, Akane Tanaka, Akira Matsuda, Kikumi Ogihara, Yuko Naya, Fusako Ikeda, Hiroshi Matsuda, Hiroki Sato, Chieko Kai   +11 more
doaj   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

CAR T cells targeting Nectin-4 safely overcome resistance to anti-Nectin-4 antibody-drug conjugate in solid tumors

Abstract Chimeric antigen receptor T (CAR T) cells represent a promising therapeutic option for a variety of cancers, including solid tumors. Nectin-4 is a cell adhesion molecule expressed at different levels in many solid tumors, including breast and urothelial carcinoma (UC).
Alexandrine Faivre, Léa Laban, Lorène Ferreira, Emmanuelle Josselin, Laurent Gorvel, Emilie Agavnian-Couquiaud, Anne Farina, Anne-Sophie Chrétien, Els Verhoeyen, Rémy Castellano, Jacques A. Nunès, Geoffrey Guittard, Marc Lopez, Daniel Olive   +13 more
openaire   +2 more sources

Role of PACAP and VIP Signalling in Regulation of Chondrogenesis and Osteogenesis [PDF]

, 2016
Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are multifunctional proteins that can regulate diverse physiological processes. These are also regarded as neurotrophic and anti-inflammatory substances in
A Akopian, A Hernanz, A Miyata, A Mobasheri, A Pan, A Sanchez, A Suzuki, A Szabo, AI Gogakos, B Botz, B Crombrugghe de, B Lv, B Sandor, B Winding, C Bataille, C Matta, CS Kovacs, CS Somogyi, D Li, D Reglodi, D Reglodi, D Reglodi, D Vaudry, E Banki, E Fabian, E Persson, EL Hohmann, G Chen, GN Onuoha, H Miraoui, H Ogawa, H Oka, H Okura, HH Strange-Vognsen, HJ Kwon, HJ Park, HW Ehlen, HW Lee, I Harfi, J Fodor, J Yang, JA Waschek, JH Jonason, JH Kim, JY Yan, K Csanaky, K Dohi, K Gelse, K Hayashi, K Schuhmann, K Tanaka, KA Pavelock, KB Paiva, L Pulsatelli, L Wang, L Zhao, M Barberi, M Carrion, M Hughes-Fulford, M Koppan, MB Goldring, MC Dvorakova, MD Payet, MJ Serrano, MM Heimesaat, MP Yavropoulou, N Ahmed, N Sangphech, N Sassi, N Shintani, P Gourlet, P Lundberg, P Niewiadomski, Q Lu, R Barrett-Jolley, R Brubel, R Yu, R Zakany, R Zakany, R Zakany, R Zhang, RL Pitts, RT Franceschi, S Giunta, S Hattori, S Onoue, S Piera-Velazquez, S Rahman, SJ Rozzi, T Juhasz, T Juhasz, T Juhasz, T Juhasz, T Juhasz, T Mustafa, TF Li, TW Moody, UH Lerner, V May, V Sethi, W Ma, Y Duan, Y Juarranz, Y Maeda, Y Rais, Y Zhang, YM Yoo, YT Konttinen   +107 more
core   +2 more sources

Productos Naturales Marinos en el tratamiento del Cancer [PDF]

, 2018
Universidad de Sevilla.
Arjona Hernández,Sara
core