Results 111 to 120 of about 10,275 (197)

Nectin-4: A promising prognostic marker and therapeutic target in cancer

Nectin cell adhesion protein 4 (Nectin-4), a calcium-independent immunoglobulin-like protein, has garnered significant attention in oncology due to its pronounced overexpression in malignant tumors and absence in healthy adult tissues. Elevated levels of Nectin-4 have been implicated in the pathogenesis of various cancers, including lung, breast, and ...
Kuttikrishnan, Shilpa, Prabhu, Kirti S., Habeeba, Ummu, Mariyam, Zahwa, Fernandes, Queenie, Maqbool, Mohsin, Khan, Omar M., Bhat, Ajaz A., Uddin, Shahab   +8 more
openaire   +4 more sources

Increased expression of ATP‐binding cassette transporters in enfortumab vedotin‐resistant urothelial cancer

IJU Case Reports
Introduction In addition to reduced nectin‐4 expression, the upregulation of ATP‐binding cassette transporters has been suggested as a potential mechanism of resistance to enfortumab vedotin.
Mariko Kotono, Toshiki Kijima, Atsuko Takada‐Owada, Naoya Okubo, Ryo Kurashina, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Kazuyuki Ishida, Takao Kamai   +9 more
doaj   +1 more source

In vitro study of lymphotropic and immunomodulatory properties of the peste des petits ruminants virus (pprv) [PDF]

, 2014
The Peste des petits ruminants (PPR) is a viral disease which affects sheep and goats and even the wild ruminants. About a billion small ruminants are found in the PPR enzootic areas.
Albina, Emmanuel, Libeau, Geneviève, Nizamani, Zaheer Ahmed, Parveen, F., Servan de Almeida, Renata   +4 more
core  

Immunhistochemische Untersuchungen zur Biologie und klinischen Bedeutung von Nektin-4 bei muskelinvasivem Blasenkrebs [PDF]

Introduction & objectives: Nectin-4, a membrane protein involved in cell adhesion, has been recently introduced as a target of the novel antibody drug conjugate Enfortumab-Vedotin (EV).
Jeršinovič, Sebastian
core   +1 more source

Enfortumab vedotin-induced bullous dermatitis [PDF]

Enfortumab vedotin is a first-in-class antibody-drug conjugate used in the treatment of locally advanced or metastatic urothelial carcinoma. A range of cutaneous adverse events has been reported with enfortumab vedotin use.
Dahiya, Madhu, Eilers, David, Fernandez, Kristen, Speiser, Jodi, Wang, Robin, Zelman, Brandon   +5 more
core   +1 more source

Effects of pregnancy on breast cancer immunology: immune biomarker and TIL quantification

npj Breast Cancer
Breast cancer diagnosed during pregnancy (PrBC) is a rare occurrence but may become more prevalent as women nowadays tend to postpone childbearing until later in life.
Kristin Galas, Moritz Gleitsmann, Julia Rey, Christine Solbach, Isabell Witzel, Thomas Karn, Sabine Schmatloch, Christian Schem, Andreas Schneeweis, Bruno Sinn, Tanja Fehm, Carsten Denkert, Peter Fasching, Anne-Sophie Litmeyer, Frederik Marmé, Paul Jank, Volkmar Müller, Sabine Seiler, Elmar Stickeler, Olaf Ortmann, Marion van Mackelenbergh, Valentina Nekljudova, Johannes Holtschmidt, Sibylle Loibl   +23 more
doaj   +1 more source

Expression of Nectin-4 protein in luminal B (HER2 negative) breast cancer [PDF]

, 2017
Cilj istraživanja: Istražiti povezanost ekspresije Nectin-4 proteina u populaciji pacijenata s luminalnim B HER2 negativnim podtipom karcinoma dojke a u korelaciji sa prognostičkim parmetrima kao što su intenzitet hormonskih receptora, Ki-67 ...
Rajc, Jasmina
core  

Entschlüsselung der metastatischen Evolution von Urothelkarzinomen - Proteom- und Transkriptom-Profilierung zur Ermittlung von Therapieresistenzmechanismen [PDF]

Hintergrund und Ziele: Die metastatische Evolution des Urothelkarzinoms, die zu klonaler Heterogenität durch den Erwerb verschiedener neuer (Treiber-)Veränderungen bzw.
Eckstein, Markus
core   +2 more sources

Roles of Nectin-4 in tumor progression

Annals of Oncology, 2015
A. Ghidouche, M. Lopez, D. Olive
openaire   +1 more source

A Case of Upper Tract Urothelial Carcinoma With Neuroendocrine Differentiation Successfully Treated With Enfortumab Vedotin and Pembrolizumab

IJU Case Reports
Introduction Upper tract urothelial carcinoma with neuroendocrine differentiation (UC‐NE) is extremely rare and generally associated with aggressive behavior and poor prognosis. Optimal treatment strategies remain unclear, particularly regarding the role
Kosei Taniguchi, Mamoru Hashimoto, Takahito Nakayama, Saizo Fujimoto, Shingo Toyoda, Takashi Kikuchi, Marco Antonio De Velasco, Osamu Maenishi, Takafumi Minami, Kazutoshi Fujita   +9 more
doaj   +1 more source