Results 151 to 160 of about 10,275 (197)

Exploring novel therapeutic targets in small bowel adenocarcinoma: insights from claudin 18.2, nectin-4, and HER3 expression analysis. [PDF]

ESMO Open
Fujii H, Shoji H, Hirano H, Hirose T, Okita N, Takashima A, Kato K.   +6 more
europepmc   +1 more source

Near-infrared photoimmunotherapy targeting Nectin-4 in a preclinical model of bladder cancer. [PDF]

Cancer Lett
Fukushima H, Takao S, Furusawa A, Valera Romero V, Gurram S, Kato T, Okuyama S, Kano M, Choyke PL, Kobayashi H.   +9 more
europepmc   +1 more source

Successful treatment with enfortumab-vedotin of metastatic signet ring cell cancer expressing nectin-4 and originating from the bladder. [PDF]

IJU Case Rep
Aoki M, Naiki T, Naiki-Ito A, Morikawa T, Matsuyama N, Torii K, Kato T, Maruyama T, Inaguma S, Yasui T.   +9 more
europepmc   +1 more source

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Role of Nectin‑4 protein in cancer (Review)

International Journal of Oncology, 2021
The Nectin cell adhesion molecule (Nectin) family members are Ca2+‑independent immunoglobulin‑like cellular adhesion molecules (including Nectins 1‑4), involved in cell adhesion via homophilic/heterophilic interplay. In addition, the Nectin family plays a significant role in enhancing cellular viability and movement ability.
Yongheng, Liu, Xiuxin, Han, Lili, Li, Yanting, Zhang, Xiaoyu, Huang, Guanghao, Li, Chuncai, Xu, Mengfan, Yin, Peng, Zhou, Fanqi, Shi, Xiaozhi, Liu, Yan, Zhang, Guowen, Wang   +12 more
openaire   +2 more sources

Nectin-4: a Novel Therapeutic Target for Skin Cancers

Current Treatment Options in Oncology, 2022
Nectin-4 is a tumor-associated antigen that is highly expressed on various cancer cells, and it has been further proposed to have roles in tumor development and propagation ranging from cellular proliferation to motility and invasion. Nectin-4 blockade reduces tumor proliferation and induces apoptosis in several malignancies.
Hiroki Hashimoto, Yuka Tanaka, Maho Murata, Takamichi Ito   +3 more
openaire   +2 more sources

Overcoming Resistance to Anti–Nectin-4 Antibody-Drug Conjugate

Molecular Cancer Therapeutics, 2022
Abstract Antibody–drug conjugates (ADC) represent a fast-growing drug class in oncology. However, ADCs are associated with resistance, and therapies able to overcome it are of utmost importance. Recently, enfortumab vedotin-ejfv (EV) was approved in nectin-4+ metastatic urothelial cancer.
Olivier Cabaud, Ludovic Berger, Emerence Crompot, José Adélaide, Pascal Finetti, Sèverine Garnier, Arnaud Guille, Nadine Carbuccia, Anne Farina, Emilie Agavnian, Max Chaffanet, Anthony Gonçalves, Emmanuelle Charafe-Jauffret, Emilie Mamessier, Daniel Birnbaum, François Bertucci, Marc Lopez   +16 more
openaire   +2 more sources

Nectin-4 has emerged as a compelling target for breast cancer

European Journal of Pharmacology, 2023
The incidence of breast cancer in women has increased year by year, becoming one of the most common malignant tumors in females worldwide. Most patients can be treated with surgery and endocrine drugs, but there are still some patients who lack effective treatment, such as triple-negative breast cancer (TNBC).
Hui Wang, Dejuan Sun, Jinxia Chen, Hua Li, Lixia Chen   +4 more
openaire   +2 more sources

Nectin-4: a Tumor Cell Target and Status of Inhibitor Development

Current Oncology Reports, 2023
This study aims to gather the current state of the literature about anti-Nectin-4 innovative associations in solid tumors and to investigate underlying resistance mechanisms.Antibody-drug conjugate (ADC) targeting Nectin-4 efficacy gained attention and offers a promising association with other antineoplastic drugs especially in urothelial carcinoma ...
Wafa Bouleftour, Paul Sargos, Nicolas Magne   +2 more
openaire   +2 more sources

Targeting Nectin-4 in Bladder Cancer

Cancer Discovery, 2017
Abstract Preliminary findings from a phase I clinical trial indicate that enfortumab vedotin, an investigational antibody–drug conjugate targeting nectin-4, shows considerable efficacy in metastatic urothelial carcinoma. Robust responses were seen even among patients with disease progression on platinum chemotherapy and/or immune ...
openaire   +2 more sources

Nectin 4 is the epithelial cell receptor for measles virus

Trends in Microbiology, 2012
Measles virus (MV) causes acute respiratory disease, infects lymphocytes and multiple organs, and produces immune suppression leading to secondary infections. In rare instances it can also cause persistent infections in the brain and central nervous system.
Ryan S, Noyce, Christopher D, Richardson
openaire   +2 more sources