An Analysis of Nectin-4 (PVRL4) in Penile Squamous Cell Carcinoma [PDF]
European Urology Open Science, 2023 Penile squamous cell carcinoma (PSCC) remains a worldwide healthcare concern with poor outcomes and inadequate therapeutic options. Molecular characterization continues to describe the intricacies of PSCC biology, which vary by human papillomavirus (HPV)
G.Daniel Grass +6 more
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Prognostic value of nectin-4 in human cancers: A meta-analysis [PDF]
Frontiers in Oncology, 2023 BackgroundMany reports have described that abnormal nectin-4 expression may be used as a prognostic marker in many tumors. However, these studies failed to reach a consensus.
Rongqiang Liu +6 more
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Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects [PDF]
BreastNectin-4 is a cell adhesion molecule which has gained more and more attention as a therapeutic target in cancer recently. Overexpression of Nectin-4 has been observed in various tumors, including breast cancer, and is associated with tumor progression ...
Yufei Wang +5 more
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Exploring Nectin-4 as a potential diagnostic biomarker in endometrial adenocarcinoma [PDF]
BMC Women's HealthBackground This study explored Nectin-4 expression in endometrial adenocarcinoma and examined its relationship with tumor grade, hormone receptor status, p53 expression, and mismatch repair (MMR) protein expression. Methods We retrospectively analyzed 55
Melike Ordu, Serife Ozlem Genc
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Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer [PDF]
Annals of Oncology, 2017 International audienceBackground: Triple-negative breast cancers (TNBCs) are associated with a poor prognosis. In contrast to other molecular sub-types, they have no identified specific target and chemotherapy remains the only available systemic ...
Yves Collette +2 more
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NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors [PDF]
Frontiers in ImmunologyIntroductionT cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of cytokines.
Cheng Wei +17 more
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Research hotspots and frontier analysis of the novel immune checkpoint Nectin-4 [PDF]
Human Vaccines & ImmunotherapeuticsNectin-4 has emerged as a pivotal therapeutic target for antibody-drug conjugates (ADCs), particularly in advanced urothelial carcinoma (aUC) research. Although extensive literature has been reported on Nectin-4, it is worth noting that no studies have ...
Yu Qiao +10 more
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Expression patterns of TROP2 and Nectin-4 in oropharyngeal squamous cell carcinoma in relation to HPV status: potential biomarkers for targeted therapy [PDF]
Therapeutic Advances in Medical OncologyBackground: Patients with inoperable or metastatic oropharyngeal squamous cell carcinoma (OSCC) face limited therapeutic options. Nectin-4, an immunoglobulin-like transmembrane adhesion protein, and Trophoblast Surface Antigen 2 (TROP2), a transmembrane ...
Charlotte Klasen +16 more
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Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers [PDF]
Molecular Cancer, 2013 BACKGROUND: Nectin-2 is a Ca(2+)-independent cell-cell adhesion molecule that is one of the plasma membrane components of adherens junctions. However, little has been reported about the involvement of Nectin-2 in cancer.
Akira Hori +8 more
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Deficient DNA mismatch repair and Nectin-4 expression in upper tract urothelial carcinoma (UTUC) [PDF]
Journal of Cancer Research and Clinical OncologyPurpose To investigate the prevalence of deficient DNA mismatch repair (dMMR) status in upper tract urothelial carcinoma (UTUC) and its association with clinicopathological characteristics as well as Nectin-4 immunohistochemical expression.
Peichen Duan +6 more
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