Results 31 to 40 of about 10,275 (197)

Gene expression of Nectin‐4 and its clinical significance in dogs with primary lung adenocarcinoma

Veterinary Medicine and Science, 2022
Background Canine primary lung adenocarcinoma (CPLA) is suspected by radiography or computed tomography; however, since there are no tumour markers, early diagnosis is difficult, and the prognosis is poor due to increased tumour volume. Nectin‐4 has been
Kei Tamura, Kumiko Ishigaki, Orie Yoshida, Terai Kazuyuki, Naoki Sakurai, Tatsuya Heishima, Tomoko Fujiyuki, Chieko Kai, Kazushi Asano   +8 more
doaj   +1 more source

Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation

Scientific Reports, 2021
Nectin-4, upregulated in various cancer cells, cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, p95-ErbB2 and ErbB2∆Ex16, enhancing DNA synthesis through the PI3K-AKT signaling in human breast cancer T47D cells in an adherent ...
Shin Kedashiro, Takeshi Kameyama, Kiyohito Mizutani, Yoshimi Takai   +3 more
doaj   +1 more source

Expression of Nectin-4 in Variant Histologies of Bladder Cancer and Its Prognostic Value-Need for Biomarker Testing in High-Risk Patients? [PDF]

, 2022
Simple Summary Variant histologies of bladder cancer present at advanced stage and are often treated with radical cystectomy. As Nectin-4 appears to be a promising target for novel therapies in conventional bladder cancer, we aimed to analyze the ...
Brinkmann, Isabel, Buchner, Alexander, Casuscelli, Jozefina, Eismann, Lennert, Ledderose, Stephan, Rodler, Severin, Schlenker, Boris, Schulz, Gerald Bastian, Sendelhofert, Andrea, Stief, Christian, Waidelich, Raphaela   +10 more
core   +1 more source

ETx-22, a Novel Nectin-4-Directed Antibody-Drug Conjugate, Demonstrates Safety and Potent Antitumor Activity in Low-Nectin-4-Expressing Tumors. [PDF]

Cancer Res Commun
Nectin-4 is a cell adhesion molecule expressed at various levels in many solid tumors, including urothelial cancer. As a means to reduce on-target skin toxicity observed with enfortumab vedotin (EV), an anti–nectin-4–monomethyl auristatin E (MMAE) antibody–drug conjugate (ADC) approved for patients with advanced urothelial cancer, 15A7.5, an anti ...
Lopez M, Crompot E, Josselin E, Farina A, Rubis M, Castellano R, Fares J, Wehbe M, Collette Y, Charafe E, Blanchin S, Romagne F, Pálfi A, Hechler T, Pahl A, Azim HA, Lhospice F, Mamessier E, Bertucci F, Elands J, Préville X, Olive D.   +21 more
europepmc   +4 more sources

Expression of nectin-4 as a potential biomarker in enzootic nasal adenocarcinoma of goats [PDF]

, 2016
The aim of this study was to test nectin-4 by immunohistochemistry as a potential biomarker in enzootic nasal adenocarcinoma (ENA) of goats. Twentyfour archival ENA case samples [from 14 male and 10 female hair goats (Capra hircus)] were used.
Aydoğan, Ahmet, Özmen, Özlem
core   +1 more source

Nectin‐4 and p63 immunohistochemical expression in canine prostate tumourigenesis [PDF]

Veterinary and Comparative Oncology, 2019
Nectin‐4 is an E‐cadherin‐based adherens junction protein of normal epithelial cells, as well as a potent mediator of anchorage‐independent cancer colony formation. It is considered a tumour‐associated histological and serological marker in various human cancers.
Della Salda, Leonardo, Massimini, Marcella, Romanucci, Mariarita, Palmieri, Chiara, Perillo, Antonella, Grieco, Valeria, Malatesta, Daniela, Spinillo, Maria Antonia, Passantino, Giuseppe, DONDI, FRANCESCO, Benazzi, Cinzia   +10 more
openaire   +5 more sources

Nectin-4 promotes osteosarcoma progression and metastasis through activating PI3K/AKT/NF-κB signaling by down-regulation of miR-520c-3p

Cancer Cell International, 2022
Purpose Nectin-4 is specifically up-regulated in various tumors, exert crucial effects on tumor occurrence and development. Nevertheless, the role and molecular mechanism of Nectin-4 in osteosarcoma (OS) are rarely studied.
Yongheng Liu, Guanghao Li, Yan Zhang, Lili Li, Yanting Zhang, Xiaoyu Huang, Xianfu Wei, Peng Zhou, Ming Liu, Gang zhao, Jinyan Feng, Guowen Wang   +11 more
doaj   +1 more source

Increased levels of nectin-4 as a serological marker for pre-eclampsia

Fujita Medical Journal, 2023
Objectives: Nectin-4 is a cell adhesion molecule with vital functions at adherens and tight junctions. Cumulative evidence now indicates that the NECTIN4 gene is overexpressed in a variety of cancers, and that the nectin-4 protein is both a disease ...
Hikari Yoshizawa, Haruki Nishizawa, Mayuko Ito, Akiko Ohwaki, Yoshiko Sakabe, Takao Sekiya, Takuma Fujii, Hiroki Kurahashi   +7 more
doaj   +1 more source

Nectin-4 Expression Is an Independent Prognostic Biomarker and Associated With Better Survival in Triple-Negative Breast Cancer

Frontiers in Medicine, 2019
Background: Triple-negative breast cancer (TNBC) represents about 10-20% of all invasive breast cancers and is associated with a poor prognosis. The nectin cell adhesion protein 4 (Nectin-4) is a junction protein involved in the formation and maintenance
Jasmin Zeindler, Savas Deniz Soysal, Savas Deniz Soysal, Salvatore Piscuoglio, Salvatore Piscuoglio, Charlotte K. Y. Ng, Robert Mechera, Robert Mechera, Andrej Isaak, Walter Paul Weber, Simone Muenst, Simone Muenst, Christian Kurzeder, Christian Kurzeder   +13 more
doaj   +1 more source

Nectin-4 significance in malignant neoplasms of the female reproductive system: a review of current data

Акушерство, гинекология и репродукция, 2020
Introduction. Nectin-4, a cell adhesion molecule of the immunoglobulin superfamily (IgSF), has been extensively studied in oncological diseases. Nectin-4 is involved in the formation of intercellular connections and promotes tumor cell proliferation ...
E. G. Romanov, K. A. Kokurina, A. A. Fedotova, Zh.E.A.K. Massolu, A. I. Andreeva, T. S. Khristoforova, R. A. Ivanova, K. V. Tarasova, M. A. Ivanov, A. E. Klyukina, M. A. Sharafan, E. V. Medvedko, M. P. Modenova   +12 more
doaj   +1 more source