Results 71 to 80 of about 10,275 (197)

The Prognostic Role of Expression of Nectin-4 in Esophageal Cancer [PDF]

Medical Science Monitor, 2019
BACKGROUND Nectin-4 is overexpressed in several human malignant tumors. This study aimed to investigate the expression of Nectin-4 in esophageal cancer tissues compared with adjacent normal esophageal tissue and its association with clinicopathological parameters and prognosis.
Lin, Xiaolong, Hu, Huijun, Pan, Yongquan, Pan, Yuping, Gao, Shuangquan   +4 more
openaire   +2 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Development of HEK293T-produced recombinant receptor-Fc proteins as potential candidates against canine distemper virus

Frontiers in Veterinary Science, 2023
Canine distemper (CD) is a highly contagious viral disease worldwide. Although live attenuated vaccine is available as a preventive measure against the disease, cases of vaccination failure highlight the importance of potential alternative agent against ...
Lingling Song, Lingling Song, Lingling Song, Hu Shan, Hu Shan, Hu Shan, Juan Huang, Juan Huang, Juan Huang   +8 more
doaj   +1 more source

Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets [PDF]

, 2017
Identification of cellular receptors and characterization of viral tropism in animal models have vastly improved our understanding of morbillivirus pathogenesis. However, specific aspects of viral entry, dissemination and transmission remain difficult to
Amerongen, G. (Geert) van, de Jong, A. (Alwin), Duprex, W.P. (William Paul), Fouchier, R.A.M. (Ron), Herfst, S. (Sander), Kuiken, T. (Thijs), Ludlow, M. (Martin), Osterhaus, A.D.M.E. (Albert), Rennick, L.J. (Linda), Riel, D.A.J. (Debby) van, Run, P.R.W.A. (Peter) van, Swart, R.L. (Rik) de, Verburgh, R.J. (Joyce), Vries, R.D. (Rory) de   +13 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Tumor expression of Nectin-4 as a prognostic marker in breast cancer

Archives of Clinical and Experimental Surgery, 2015
Background: Identification of new molecular tumor associated biomarkers is the most important current challenge in cancer research. Nectin-4 is one of the Nectin glycoproteins, which are cell adhesion molecules have been involved in tumor biology ...
Hisham Al-Torky, Galal Aboul-Nagah, Tarek El-Fayomi, Hytham Fayed, Hanan Tayel, Mahmoud Sakr   +5 more
doaj   +1 more source

Expression and clinical significance of Nectin-4 in hepatocellular carcinoma

OncoTargets and Therapy, 2016
Nectin-4 is a member of the Nectin family of four Ca(+)-independent immunoglobulin-like cell adhesion molecules and implicated in cell adhesion, movement, proliferation, differentiation, polarization, and survival. The aberrant expression of Nectin-4 has been found in a variety of tumors; however, its expression in hepatocellular carcinoma (HCC) is ...
Xu, Geliang, Ma,Jie, Sheng,Zhiyong, Lv,Yang, Liu,Wenbin, Yao,Qiyang, Pan,Tingting, Xu,Zhijun, Zhang,Chuanhai   +8 more
openaire   +4 more sources

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Nectin-4 and DNA mismatch repair proteins expression in upper urinary tract urothelial carcinoma (UTUC) as a model for tumor targeting approaches: an ImGO pilot study

BMC Cancer, 2022
Background Upper urinary tract urothelial carcinoma (UTUC) accounts for only about 5–10% of all urothelial cancers and is characterized by an aggressive and frequently rapidly fatal behavior.
Maria Letizia Calandrella, Simona Francesconi, Cecilia Caprera, Claudia Mosillo, Claudia Caserta, Diana Giannarelli, Matteo Corsi, Serena Macrini, Annalisa Guida, Stefano Ascani, Sergio Bracarda   +10 more
doaj   +1 more source

Cutting‐edge advances in bicyclic peptide‐based radiotracers for cancer imaging and theranostics

VIEW, EarlyView.
Abstract Along with successful clinical approval of radiopharmaceuticals targeting somatostatin receptor subtype 2 and prostate‐specific membrane antigen, peptide‐based radiotracers have garnered the increasing attention in cancer imaging and theranostics. As a newly emerging targeting ligand in recent years, bicyclic peptides have demonstrated immense
Hengyi Ou, Xiaobo Wang, Fei Kang
wiley   +1 more source