Results 151 to 160 of about 4,349,033 (348)
The problem of labels in e-assessment of diagrams [PDF]
, 2008 In this short paper we explore a problematic aspect of automated assessment of diagrams. Diagrams have partial and sometimes inconsistent semantics.
Jayal, A, Shepperd, M J
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Urbanization Sans Development? [PDF]
From a theoretical standpoint, the question has to be asked whether or not the census should retain its present definition of urban areas. There is a need for a more meaningful integration of the structural, institutional and demographic criteria, if the
Flieger, Wilhelm, Gultiano, Socorro A.
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PENEMPATAN SUARA (VOCAL PLACEMENT) DALAM SENI OLAH VOKAL BALI [PDF]
, 2006 I would like to open hiding clue in vocal techniques as an artistic treasure of Balinese culture. Many people who are expert in this particular genre designedly or involuntary have done and even in advance technique. The fact that traditional singers are
Desak Made , Suarti Laksmi
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A SCIENTIFIC ACCOUNT OF MEANING: DEFLATIONARY BUT NOT DISENCHANTING
Zygon, 2009 In The Really Hard Problem, Owen Flanagan maintains that accounting for meaning requires going beyond the resources of the physical, biological, social, and mind sciences.
doaj +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Controlled vocabularies and semantics in systems biology [PDF]
, 2011 The use of computational modeling to describe and analyze biological systems is at the heart of systems biology. Model structures, simulation descriptions and numerical results can be encoded in structured formats, but there is an increasing need to ...
Courtot, Mélanie, Hucka, Michael
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source