Results 101 to 110 of about 8,013,226 (281)
The need for a more ambitious structure of governance to face new challenges within the EU
Frontiers in Political ScienceNeo-functionalism, intergovernmentalism and a political economy of national self-interest have characterised a process of European integration that was strongly oriented towards the full realisation of the three freedoms.
Javier Bilbao-Ubillos
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The Need for Aerospace Structural Health Monitoring
International Journal of Prognostics and Health Management, 2021 Aircraft accidents involving catastrophic fatigue failure have the potential for significant loss of life. The aim of this research was to investigate trends in aircraft fatigue failure accidents to inform aerospace Structural Health Monitoring (SHM) system Research and Development (R&D).
Graham Wild +3 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Protein Structure Classification and Loop Modeling Using Multiple Ramachandran Distributions
Computational and Structural Biotechnology Journal, 2017 Recently, the study of protein structures using angular representations has attracted much attention among structural biologists. The main challenge is how to efficiently model the continuous conformational space of the protein structures based on the ...
Seyed Morteza Najibi +4 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
A fresh look at the Ramachandran plot and the occurrence of standard structures in proteins
Biomolecular Concepts, 2010 The Ramachandran plot is among the most central concepts in structural biology, seen in publications and textbooks alike. However, with the increasing numbers of known protein structures and greater accuracy of ultra-high resolution protein structures ...
Hollingsworth Scott A. +1 more
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The characteristic electronic structure needed for high-temperature superconductivity
Chemical Physics Letters, 1991 Abstract It is shown that the magnon mechanism proposed by Goddard and co-workers to explain high-temperature superconductivity in oxidized cuprates can also account for such superconductivity in both oxidized barium bismuthate and the electron superconductors based on neodynium cuprate.
Pyper, N, Edwards, P
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source