Results 81 to 90 of about 89,629,379 (296)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

COVAXIN approval : Need for recognition [PDF]

open access: yes, 2021
Although it is expected that the COVAXIN will get recognized by end of August, what needs to be understood is the repercussion faced till now and possible pitfalls in case there is further delay.
Gupta, Biswanath, Mehrotra, Abhinav
core  

Need Support in Students with Visual Impairments: Comparing Teacher and Student Perspectives

open access: yesFrontiers in Education, 2018
According to self-determination theory (SDT), need-supportive teaching positively influences students’ engagement to learn. Need-supportive teaching involves teachers providing students with structure, autonomy support, and involvement.
Ineke Haakma   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Genetic diversity of Morato's Digger Toad, Proceratophrys moratoi: spatial structure, gene flow, effective size and the need for differential management strategies of populations

open access: yesGenetics and Molecular Biology, 2017
The Morato's Digger Toad, Proceratophrys moratoi, is a critically endangered toad species with a marked population decline in southern Brazilian Cerrado.
Mauricio P. Arruda   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

A Moderating Role of Personal Need for Structure on the Effects of Process versus Outcome Simulations on the Evaluation of Really New Products

open access: yesAsia Marketing Journal, 2013
Really new products (RNPs) provide novel benefits yet many consumers are reluctant to accept these highly innovative new products. Previous literature has shown that mental simulation is an ef-fective method for enhancing the evaluation of RNPs. However.
Jun San Kim   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The need for a more ambitious structure of governance to face new challenges within the EU

open access: yesFrontiers in Political Science
Neo-functionalism, intergovernmentalism and a political economy of national self-interest have characterised a process of European integration that was strongly oriented towards the full realisation of the three freedoms.
Javier Bilbao-Ubillos
doaj   +1 more source

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