Results 111 to 120 of about 8,032,251 (282)

The need for a more ambitious structure of governance to face new challenges within the EU

Frontiers in Political Science
Neo-functionalism, intergovernmentalism and a political economy of national self-interest have characterised a process of European integration that was strongly oriented towards the full realisation of the three freedoms.
Javier Bilbao-Ubillos
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The Need for Aerospace Structural Health Monitoring

International Journal of Prognostics and Health Management, 2021
Aircraft accidents involving catastrophic fatigue failure have the potential for significant loss of life. The aim of this research was to investigate trends in aircraft fatigue failure accidents to inform aerospace Structural Health Monitoring (SHM) system Research and Development (R&D).
Graham Wild, Luke Pollock, Ayah Khalid Abdelwahab, John Murray   +3 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Protein Structure Classification and Loop Modeling Using Multiple Ramachandran Distributions

Computational and Structural Biotechnology Journal, 2017
Recently, the study of protein structures using angular representations has attracted much attention among structural biologists. The main challenge is how to efficiently model the continuous conformational space of the protein structures based on the ...
Seyed Morteza Najibi, Mehdi Maadooliat, Lan Zhou, Jianhua Z. Huang, Xin Gao   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A fresh look at the Ramachandran plot and the occurrence of standard structures in proteins

Biomolecular Concepts, 2010
The Ramachandran plot is among the most central concepts in structural biology, seen in publications and textbooks alike. However, with the increasing numbers of known protein structures and greater accuracy of ultra-high resolution protein structures ...
Hollingsworth Scott A., Karplus P. Andrew   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The characteristic electronic structure needed for high-temperature superconductivity

Chemical Physics Letters, 1991
Abstract It is shown that the magnon mechanism proposed by Goddard and co-workers to explain high-temperature superconductivity in oxidized cuprates can also account for such superconductivity in both oxidized barium bismuthate and the electron superconductors based on neodynium cuprate.
Pyper, N, Edwards, P
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source