Results 121 to 130 of about 2,206,742 (262)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Training needs analysis of surgical teams in Somaliland. [PDF]

Br J Surg
McKnight G, Daoud HA, Friebel R, Hargest R.   +3 more
europepmc   +1 more source

Antenatal ultrasound needs-analysis survey of Australian rural/remote healthcare clinicians: recommendations for improved service quality and access. [PDF]

BMC Public Health, 2023
Bidner A, Bezak E, Parange N.
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Needs analysis of learning objectives for a lifestyle medicine curriculum in family medicine residency program: an E-Delphi study. [PDF]

BMC Prim Care
Mevsim V, Özkaya Y, Başer DA, İşcan G, İmançer MS, Çöme O, Günvar T, Yurdabakan I.   +7 more
europepmc   +1 more source

Oral health ambassador scheme: training needs analysis in the community setting. [PDF]

Br Dent J, 2022
Archer N, Martin K, Johnston L.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Developing a Training Program for Healthcare Data Professionals in South Korea: A Needs Analysis. [PDF]

Healthc Inform Res
Kim Y, Moon Y, Jung J, Jeung S, Ji YA, Kim G, Lee Y, Woo H.   +7 more
europepmc   +1 more source

The prevalence of health risk behavior engagement among grade 4 to 7 learners in primary schools: A phase one needs analysis. [PDF]

J Public Health Afr, 2023
Daniels KJ, Pharaoh H.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source