Results 121 to 130 of about 2,743,843 (310)
Training needs analysis: an empirical study of the Abu Dhabi police [PDF]
, 2014 This thesis was submitted for the degree of Doctor of philosophy and awarded by Brunel UniversityTraining Needs Analysis (TNA) is often considered the most important step among the stages in the training cycle and, therefore, should precede any training ...
Ghufli, Ali-Hamad Badi
core
The analysis of architectural languages for the needs of practitioners
Software: Practice and Experience, 2018 SummaryArchitectural languages (ALs) have attracted much attention as the modeling notations for specifying and reasoning about important design decisions. In this study, 124 different existing ALs have been analyzed for a set of requirements that are crucial for practitioners.
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A Task-based Needs Analysis for the English Language Institute at the University of Hawai'I at Manoa
This study investigates ESL students’ needs in EAP (English for Academic Purposes) program. Specifically, this research focuses on diverse attributes that potentially determine learners’ needs in EAP courses in terms of perceived task frequency ...
Kong, Don-Kwan +4 more
core
Internationalization of Business English communication at university: A threefold needs analysis
Ibérica, 2013 This paper provides an example of a thorough needs analysis previous to the syllabus planning of a Business English (BE) course at a Catalan university. Three types of sources for linguistic needs are considered.
Guzmán Macho Barés, Enric Llurda
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source