Results 151 to 160 of about 2,206,742 (262)

Developing a competence framework for gerontological nursing in China: a two-phase research design including a needs analysis and verification study. [PDF]

BMC Nurs, 2022
Dijkman BL, Hirjaba M, Wang W, Palovaara M, Annen M, Varik M, Cui Y, Li J, van Slochteren C, Jihong W, Feiteng C, Luo Y, Chen Y, Paans W.   +13 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A preliminary study on the development of a chronic disease self-management curriculum for disability support workers: educational needs analysis. [PDF]

BMC Public Health
Park HN, Nam HJ, Lee Msn H, Lee S, Kim B, Yoon JY.   +5 more
europepmc   +1 more source

Interprofessional Needs Analysis and User-Centred Prototype Evaluation as a Foundation for Building Individualized Digital Education in Dementia Healthcare Supported by Artificial Intelligence: A Study Protocol. [PDF]

Healthcare (Basel), 2023
Malek M, Nitsche J, Dinand C, Ehlers J, Lissek V, Böhm P, Derksen EM, Halek M.   +7 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Correction: Close to the border-Resilience in healthcare in a European border region: Findings of a needs analysis. [PDF]

PLoS One
Loeffler LAK, Lambert SI, Bouché L, Klasen M, Sopka S, Vogt L.   +5 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Drivers and determinants of extreme humanitarian needs among Rohingya refugee households: Evidence from UNHCR's multi-sectoral needs analysis. [PDF]

PLoS One
Wilson H.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Enhancing Maritime Safety Through Needs Analysis: Identifying Critical English Communication Skills for Pre-Service Maritime Students in a Chinese University. [PDF]

Behav Sci (Basel)
Guo X, Zhen M, Guo Y.
europepmc   +1 more source