Results 171 to 180 of about 8,522,636 (303)

Aligning AI affordances with critical thinking skills in Chinese EFL: a discrepancy-based needs analysis for an AI-integrated blended reading module. [PDF]

Front Psychol
Yang A, Dong L.
europepmc   +1 more source

Interprofessional Needs Analysis and User-Centred Prototype Evaluation as a Foundation for Building Individualized Digital Education in Dementia Healthcare Supported by Artificial Intelligence: A Study Protocol. [PDF]

Healthcare (Basel), 2023
Malek M, Nitsche J, Dinand C, Ehlers J, Lissek V, Böhm P, Derksen EM, Halek M.   +7 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Areaalzheimer: development of a digital platform for caregivers based on the results of a needs analysis and mixed-methods pilot evaluation process. [PDF]

Front Digit Health
Piromalli D, Cañadas-Romero MA, Ivirico-Prats M, Suárez-Calvet M, Beriain Bañares A, Sánchez-Valle M, Ortíz-Castelví L.   +6 more
europepmc   +1 more source

A gaps-and-needs analysis of vaccine R&D in Europe: Recommendations to improve the research infrastructure. [PDF]

Biologicals, 2022
Jungbluth S, Depraetere H, Slezak M, Christensen D, Stockhofe N, Beloeil L.   +5 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A preliminary study on the development of a chronic disease self-management curriculum for disability support workers: educational needs analysis. [PDF]

BMC Public Health
Park HN, Nam HJ, Lee Msn H, Lee S, Kim B, Yoon JY.   +5 more
europepmc   +1 more source

Developing a competence framework for gerontological nursing in China: a two-phase research design including a needs analysis and verification study. [PDF]

BMC Nurs, 2022
Dijkman BL, Hirjaba M, Wang W, Palovaara M, Annen M, Varik M, Cui Y, Li J, van Slochteren C, Jihong W, Feiteng C, Luo Y, Chen Y, Paans W.   +13 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Drivers and determinants of extreme humanitarian needs among Rohingya refugee households: Evidence from UNHCR's multi-sectoral needs analysis. [PDF]

PLoS One
Wilson H.
europepmc   +1 more source