Results 171 to 180 of about 2,206,742 (262)

Investigating Saudi university medical students' English language difficulties: a needs analysis study. [PDF]

Front Med (Lausanne)
Alrashed M, Abdel Latif MMM.
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Improving primary healthcare quality in China through training needs analysis. [PDF]

Sci Rep
Liu B, Xue Q, Li X, Sun J, Rao Z, Zou G, Li X, Yin Z, Zhang X, Tian Y, Zhang M.   +10 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

A Training Needs Analysis for AI and Generative AI in Medical Education: Perspectives of Faculty and Students. [PDF]

J Med Educ Curric Dev
McCoy L, Ganesan N, Rajagopalan V, McKell D, Niño DF, Swaim MC.   +5 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Integrate & balance aspects for safe and sustainable innovation: Needs analysis on SSbD categories and product development stage requirements to cover the entire life cycle. [PDF]

Comput Struct Biotechnol J
Larrea-Gallegos GM, Hofer S, Hofstätter N, Punz B, Watzek N, Lölsberg W, Wiench K, Wohlleben W, Aguirre IG, Athanassios N, Sarimveis H, Costa A, Seitz C, Friedrichs S, Exner TE, Hischier R, Marvuglia A, Himly M.   +17 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Training Needs Analysis for Medical Students in Assessing Cognitive Functioning: An Observational Study. [PDF]

Indian J Psychol Med
Bohra A, Jyotsna M, Pereddy SDGR, Sampath A, Rozatkar AR, Coulter RW, Gupta S.   +6 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source