FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
An Evaluation of “Special Educational Needs” Programmes in England [PDF]
The need for education to help every child rather than focus on average attainment has become a more central part of the policy agenda in the US and the UK.
Francois Keslair +2 more
core
User Perceptions and Needs Analysis of a Virtual Coach for Active and Healthy Ageing-An International Qualitative Study. [PDF]
Int J Environ Res Public Health, 2022 Möller J +14 more
europepmc +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Status and Needs Analysis of Korean Medicine Doctors' Continuing Professional Development. [PDF]
J PharmacopunctureCho EB +8 more
europepmc +1 more source
Limitations in activities of daily living and support needs - Analysis of GEDA 2019/2020-EHIS. [PDF]
J Health Monit, 2022 Fuchs J, Gaertner B, Prütz F.
europepmc +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Aligning AI affordances with critical thinking skills in Chinese EFL: a discrepancy-based needs analysis for an AI-integrated blended reading module. [PDF]
Front PsycholYang A, Dong L.
europepmc +1 more source
Interprofessional Needs Analysis and User-Centred Prototype Evaluation as a Foundation for Building Individualized Digital Education in Dementia Healthcare Supported by Artificial Intelligence: A Study Protocol. [PDF]
Healthcare (Basel), 2023 Malek M +7 more
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source