Results 181 to 190 of about 2,743,843 (310)

Areaalzheimer: development of a digital platform for caregivers based on the results of a needs analysis and mixed-methods pilot evaluation process. [PDF]

Front Digit Health
Piromalli D, Cañadas-Romero MA, Ivirico-Prats M, Suárez-Calvet M, Beriain Bañares A, Sánchez-Valle M, Ortíz-Castelví L.   +6 more
europepmc   +1 more source

A gaps-and-needs analysis of vaccine R&D in Europe: Recommendations to improve the research infrastructure. [PDF]

Biologicals, 2022
Jungbluth S, Depraetere H, Slezak M, Christensen D, Stockhofe N, Beloeil L.   +5 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A preliminary study on the development of a chronic disease self-management curriculum for disability support workers: educational needs analysis. [PDF]

BMC Public Health
Park HN, Nam HJ, Lee Msn H, Lee S, Kim B, Yoon JY.   +5 more
europepmc   +1 more source

Developing a competence framework for gerontological nursing in China: a two-phase research design including a needs analysis and verification study. [PDF]

BMC Nurs, 2022
Dijkman BL, Hirjaba M, Wang W, Palovaara M, Annen M, Varik M, Cui Y, Li J, van Slochteren C, Jihong W, Feiteng C, Luo Y, Chen Y, Paans W.   +13 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Drivers and determinants of extreme humanitarian needs among Rohingya refugee households: Evidence from UNHCR's multi-sectoral needs analysis. [PDF]

PLoS One
Wilson H.
europepmc   +1 more source

Supporting Self-Directed Learning: A National Needs Analysis. [PDF]

Med Sci Educ, 2021
Lim YS, Lyons VT, Willey JM.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Correction: Close to the border-Resilience in healthcare in a European border region: Findings of a needs analysis. [PDF]

PLoS One
Loeffler LAK, Lambert SI, Bouché L, Klasen M, Sopka S, Vogt L.   +5 more
europepmc   +1 more source