Results 221 to 230 of about 30,536,190 (264)

Unmet Need for Family Planning Among Married Women in Bangladesh: A Decade of Progress and Persisting Disparities. [PDF]

Int J Health Plann Manage
Yasmin S, Koasha FA, Islam MR, Ali MH, Huq MN.   +4 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Actions Reported by Physicians With Large Improvements in Burnout and Professional Fulfillment.

JAMA Netw Open
Shanafelt TD, Makowski MS, Hale B, Carlasare LE, Menon NK, Shapiro A, Wang H, Tutty M, Trockel MT, Sinsky C.   +9 more
europepmc   +1 more source

Study on Natural Background Levels of Iron and Manganese in Groundwater of Yinchuan Plain. [PDF]

Water Environ Res
Cao C, Li Y, Li X, Ren Y, Wang Y, Lu C, Wang Y.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effects of web-based palliative wound care education using the clinical judgment model: A quasi-experimental study with facilitylevel random allocation. [PDF]

J Korean Gerontol Nurs
Chang SO, Kim D, Choi YR, Kwon DY, Lee YN.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Patient Participation in Organ Transplant Selection Meetings: A Qualitative Study.

JAMA Netw Open
Graham N, Meyer A, Jager Z, Stover M, Dale LA, Ramos J, Kennefick K, Bhatnagar N, Dorf-Kamienny S, Ladin K, Pawar AS.   +10 more
europepmc   +1 more source

Early predictive value of prediction models for mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis. [PDF]

Front Cardiovasc Med
Wang R, He M, Yuan Z, Zhou J, Han L, Cheng X, Chen Y, Wang F.   +7 more
europepmc   +1 more source