Results 21 to 30 of about 9,190 (201)

Effects of SGLT2 inhibitors across the spectrum of albuminuria in cardiovascular–kidney–metabolic conditions: A pooled analysis of randomised trials

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1105-1115, February 2026.
Abstract Background Albuminuria is associated with an increased risk of cardiovascular and kidney events. Sodium glucose co‐transporter 2 inhibitors (SGLT2i) reduce albuminuria and improve kidney outcomes in patients with albuminuric chronic kidney disease (CKD).
João Pedro Ferreira, Pedro Marques, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Abhinav Sharma, Francisco Vasques‐Nóvoa, Luís Mendonça, João Sérgio Neves, Milton Packer, Faiez Zannad   +10 more
wiley   +1 more source

Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk, Ilse Gille, Carolt Arana, Jordi Rovira, Eduard Palou, Fritz Diekmann, Dave L. Roelen, Mirjam H. M. Heemskerk, Sebastiaan Heidt   +8 more
wiley   +1 more source

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 23: Suitability of taxonomic units notified to EFSA until September 2025

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The qualified presumption of safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of relevant knowledge and safety of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Ingvar Sundh, Fulvio Barizzone, Justine Dastouet, Nadya Doyle, Sandra Correia, Lieve Herman   +28 more
wiley   +1 more source

The Role of Albuminuria in Diagnosing and Stratifying Kidney Disease in Heart Transplant Recipients: A KDIGO Criteria‐Based Analysis

Clinical Transplantation, Volume 39, Issue 12, December 2025.
ABSTRACT Background Chronic kidney disease (CKD) is a common but poorly characterized complication in heart transplant (HT) recipients due to limited use of renal damage markers, such as albuminuria. Our aim is to determine CKD prevalence based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria, assess CKD risk stratification according ...
Pedro Caravaca‐Pérez, Anthony Salazar Rodriguez, José Jesús Broseta, Eduard Solé Gonzalez, María Ángeles Castel, Juan José Rodriguez, Elena Cuadrado‐Payán, Diana Rodriguez‐Espinosa, Elena Sandoval, Aleix Cases, Ana García‐Álvarez, Marta Farrero   +11 more
wiley   +1 more source

Sodium–glucose co‐transporter 2 inhibitors in severe estimated glomerular filtration rate deterioration across cardiovascular‐kidney‐ metabolic conditions: A pooled analysis of randomized trials

European Journal of Heart Failure, Volume 27, Issue 11, Page 2433-2441, November 2025.
Aims The efficacy of sodium–glucose co‐transporter 2 inhibitors (SGLT2i) among patients with cardiovascular‐kidney‐metabolic (CKM) conditions who experience severe estimated glomerular filtration rate (eGFR) deterioration during follow‐up is not well established.
João Pedro Ferreira, Pedro Marques, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Abhinav Sharma, Francisco Vasques‐Nóvoa, Luís Mendonça, João Sérgio Neves, Milton Packer, Faiez Zannad   +10 more
wiley   +1 more source

Comorbidity and Malnutrition as Key Determinants of Mortality in Elderly Haemodialysis Patients: A One‐Year Observational Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background In elderly haemodialysis patients, poor functional status correlates with malnutrition, morbidity and mortality. This study aimed to assess 1‐year survival in an elderly haemodialysis population and evaluate the predictive capacity of commonly used scales for comorbidity, malnutrition, dependence and frailty.
M. L. Sanchez‐Tocino, S. Mas‐Fontao, E. González‐Parra, P. Manso, M. Burgos, D. Carneiro, M. Pereira, C. Pereira, A. Lopez‐González, M. D. Arenas, on behalf the renal foundation work team   +10 more
wiley   +1 more source

STING inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis

The Journal of Pathology, Volume 267, Issue 2, Page 196-212, October 2025.
Abstract Peritoneal dialysis (PD) is a widely used kidney replacement therapy for patients with end‐stage kidney disease. Nevertheless, long‐term exposure to PD fluid can damage the peritoneal membrane, leading to ultrafiltration failure and, ultimately, discontinuation of PD.
Vanessa Marchant, Jorge García‐Giménez, Guadalupe T González‐Mateo, Pilar Sandoval, Lucía Tejedor‐Santamaria, Sandra Rayego‐Mateos, Ricardo Ramos, José A Jiménez‐Heffernan, Alberto Ortiz, Anne‐Catherine Raby, Manuel López‐Cabrera, Adrián M Ramos, Marta Ruiz‐Ortega   +12 more
wiley   +1 more source

Associated Factors to Nonadherence to Routine Appointments after Kidney Transplantation: The ADHERE Brazil Study

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Rationale Nonadherence to routine outpatient appointments (NApp) post kidney transplantation (KT) is a poorly studied health behavior associated with unfavorable outcomes. In the ADHERE BRAZIL Study, we previously reported a high prevalence of this behavior (12.7%).
Roberta Lopes Karlburger, João Henrique Sendrete de Pinho, Fernando Antônio Basile Colugnati, Kris Denhaerynck, José Osmar Pestana Medina, Tainá Veras de Sandes‐Freitas, Sabina De Geest, Helady Sanders‐Pinheiro, the ADHERE BRAZIL Study Team   +8 more
wiley   +1 more source

Tubulointerstitial Nephritis Post‐Microsporidium Infection in a Combined Liver–Kidney Transplanted Patient: A Case Report

Nephrology, Volume 30, Issue 9, September 2025.
ABSTRACT Microsporidia are emerging opportunistic pathogens in immunosuppressed individuals, including solid organ transplant recipients. We present a case of tubulointerstitial nephritis (TIN) caused by Microsporidia infection in a 55‐year‐old male who underwent combined liver–kidney transplantation (CLKT) for metabolic‐associated fatty liver disease ...
Alfonso Gindl‐Bracho, Hector O. Rivera‐Villegas, Norma O. Uribe‐Uribe, Luis E. Morales‐Buenrostro, Alejandro Schcolnik‐Cabrera   +4 more
wiley   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz‐Esquiroz, Javier Gómez‐Ambrosi, Emma Chávez‐Manzanera, Verónica Vázquez‐Velázquez, Jean‐Michel Oppert, Dimitrios N. Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco   +28 more
wiley   +1 more source