Results 71 to 80 of about 10,324 (207)

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Light curve solutions of six eclipsing binaries at the lower limit of periods of the W UMa stars

, 2015
Photometric observations in V and I bands of six eclipsing binaries at the lower limit of the orbital periods of W UMa stars are presented. Three of them are newly discovered eclipsing systems.
Dimitrov, Dinko P., Ibryamov, Sunay I., Kjurkchieva, Diana P.   +2 more
core   +1 more source

From narratives to numbers and back: Assessing the psychosocial aspects of diabetes in the era of high technology with emerging qualitative and quantitative methodologies

Diabetic Medicine, EarlyView.
Abstract Aims Rapid changes in diabetes therapy combined with limitations of traditional methodological approaches challenge the field of psychosocial research to adequately capture the experiences of people with diabetes. This narrative review provides an overview of emerging qualitative and quantitative approaches that can advance the study of ...
Dominic Ehrmann, Eloise Litterbach, Sonya Deschenes, Rita Forde, Norbert Hermanns, Maaike Horsselenberg, Mandy Jansen, Amy McInerney, Eimear Morrissey, Andreas Schmitt, Uffe Søholm, Giesje Nefs   +11 more
wiley   +1 more source

Psychosocial aspects of early detection in type 1 diabetes: Language matters, decision making and support needs

Diabetic Medicine, EarlyView.
Abstract Aim The potential implementation of early type 1 diabetes (T1D) detection pathways, encompassing autoantibody screening and longitudinal monitoring, raises important psychosocial considerations for ethical, person‐centred care. This review summarises evidence on the psychosocial impact of early T1D detection, identifying key evidence gaps and ...
Maartje de Wit, Laura Yvonne Klinker, Belinda Moore, Anna Boggiss, Lucía Feito Allonca, Mariam Asaad, Keely Bebbington, Bryan Cleal, Sasja Huisman, Per Winterdijk, Henk Jan Aanstoot, Christine Fransman, Elizabeth Holmes‐Truscott, Norbert Hermanns, Giesje Nefs   +14 more
wiley   +1 more source

The nucleotide exchange factors of Hsp70 molecular chaperone

Frontiers in Molecular Biosciences, 2015
Molecular chaperones of the Hsp70 family form an important hub in the cellular protein folding networks in bacteria and eukaryotes, connecting translation with the downstream machineries of protein folding and degradation.
Andreas eBracher, Jacob eVerghese
doaj   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Discovery and characterisation of detached M-dwarf eclipsing binaries in the WFCAM Transit Survey

, 2012
We report the discovery of 16 detached M-dwarf eclipsing binaries with ...
Aigrain, Aigrain, Allard, Andersen, Andersen, Bailer-Jones, Bakos, Baraffe, Barrado y Navascués, Bas Nefs, Batalha, Bender, Berger, Bessell, Birkby, Bonanos, Brigitta Sipőcz, Carter, Casali, Chabrier, Chabrier, Claret, Claret, Covey, Cruz, David Barrado, David Pinfield, de Mooij, Deeg, Demory, Dhital, Dimitris Mislis, Doyle, Drimmel, Dunham, Eduardo Martin, Enric Palle, Ernst de Mooij, Etzel, Felipe Murgas, Girardi, Gizis, Guinan, Gustafsson, Gábor Kovács, Hartman, Henry, Hewett, Hillenbrand, Hoaglin, Hodgkin, Hristo Stoev, Huélamo, Ignas Snellen, Irwin, Irwin, Irwin, Irwin, Irwin, Irwin, Jackson, Jayne Birkby, Jeffries, Johnson, Jones, Kervella, Kirkpatrick, Knigge, Koppenhoefer, Kovacs, Kraus, Law, Lawrence, Leggett, Lodieu, Lucy, Lépine, López-Morales, López-Morales, Mann, Markwardt, Michele Cappetta, Miller, Morales, Morales, Muirhead, Mullan, Munn, Munn, Nefs, Nelson, Niall Goulding, Nicolas Lodieu, Nordstrom, Nutzman, Parsons, Parsons, Patricia Cruz, Pollacco, Pont, Popper, Popper, Press, Pyrzas, Reid, Reylé, Ribas, Ribas, Roberto Saglia, Rojas-Ayala, Schlegel, Shkolnik, Simon Hodgkin, Skrutskie, Slesnick, Soderblom, Southworth, Southworth, Southworth, Southworth, Southworth, Southworth, Southworth, Southworth, Stassun, Ségransan, Torres, Torres, Vaccaro, van Hamme, Viti, Viti, West, Woolf, Woolf, Yakiv Pavlenko, York, Zahn, Zahn, Zucker, Önehag   +140 more
core   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Boundedness of Variance Functions of Natural Exponential Families with Unbounded Support

Mathematics
The variance function (VF) is central to natural exponential family (NEF) theory. Prompted by an online query about whether, beyond the classical normal NEF, other real-line NEFs with bounded VFs exist, we establish three complementary sets of sufficient
Shaul K. Bar-Lev
doaj   +1 more source

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

The FEBS Journal, EarlyView.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff, Paolo De Los Rios, Mathieu E. Rebeaud   +2 more
wiley   +1 more source