Results 61 to 70 of about 8,335,736 (280)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Negative-pressure Wound Therapy for Periocular Necrotizing Fasciitis

Plastic and Reconstructive Surgery, Global Open, 2018
Summary:. Periocular necrotizing fasciitis is a rare, but potentially blinding, or even fatal disease. The authors report a case of a 44-year-old man who presented with quiescent bilateral periocular and facial necrotizing fasciitis.
John W. Gillespie, III, MD, Jui K. Pandya, MD, Shilpa M. Agarwal, MD, Andrew A. Gassman, MD, Mark Krakauer, MD, MPhil   +4 more
doaj   +1 more source

Negative pressure wound therapy in patients with diabetic foot

Acta Orthopaedica et Traumatologica Turcica, 2020
Objective: In this study our aim was to compare the results of standard dressing treatment to negative pressure wound therapy (NPWT) performed with a vacuum-assisted closure (VAC) device in patients with diabetic foot ulcers. \r\nMethods: We assessed the
Ali Engin Ulusal, M. Sukru Sahin, Betul Ulusal, Gokhan Cakmak, Cengiz Tuncay   +4 more
doaj   +1 more source

The modulation of the burn wound environment by negative pressure wound therapy: Insights from the proteome

, 2020
Negative pressure wound therapy has been used to promote wound healing in a variety of settings, including as an adjunct to silver‐impregnated dressings in the acute management of paediatric burns.
Griffin, BR, Zang, T, Cuttle, L, Parker, TJ, McPhail, SM, Frear, CC, Kimble, RM   +6 more
core   +1 more source

Modern alternative or first-line treatment: How to safely use Negative Pressure Wound Therapy in Diabetic Foot Syndrome? [PDF]

, 2015
Clinical experience and basic science studies show that Negative Pressure Wound Therapy (NPWT) is a promising yet still under-used treatment method for patients with diabetic foot syndrome (DFS).
Mrozikiewicz-Rakowska, Beata, Nowak, Adrianna, Kania, Joanna, Chojnowski, Marek, Bucior, Ewelina, Krzymień, Janusz   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Negative Pressure Wound Therapy for Necrotizing Fasciitis and Compartment Syndrome of the Upper Extremity — a case report [PDF]

, 2019
Background: Necrotizing fasciitis (NF) is a lifethreateninginfection of the subcutaneous tissues that spreadsalong the underlying fascia. Despite the early and aggressivesurgical fasciotomy and necrectomy, its mortality rate is stillhigh.
Szentkereszty, Zsolt, Susán, Zsolt, Bazsó, Tamás, Mudriczki, Gábor, Győry, Ferenc, Enyedi, Attila, Damjanovich, László   +6 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Clinical and cost-effectiveness of negative pressure wound therapy versus usual care for surgical wounds healing by secondary intention: the SWHSI 2 pragmatic RCT

Health Technology Assessment
Background Surgical wounds healing by secondary intention occur if a surgical wound is not closed or dehisces following primary closure. Surgical wounds healing by secondary intention are common and adversely affect patients’ quality of life.
Catherine Arundel, Laura Mandefield, Caroline Fairhurst, Kalpita Baird, Pedro Saramago, Athanasios Gkekas, Rhiannon Macefield, Jane Blazeby, Belen Corbacho, Stephen Dixon, Jo Dumville, Josie Hatfield, Catherine Hewitt, Matthew Lee, Andrew Mott, Angela Oswald, Thomas Pinkney, Nikki Stubbs, Samantha Swan, David Torgerson, Jacqueline Wilkinson, Lyn Wilson, Sabeen Zahra, Ian Chetter   +23 more
doaj   +1 more source