Results 81 to 90 of about 8,335,736 (280)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Management of large chronic venous leg ulcers with negative pressure wound therapy [PDF]

, 2017
Introduction: Venous leg ulcers (VLU) occur in 1\% of the adult population and are associated with chronic disability, diminished quality of life and high health-care costs.
Bartosz Szymański, Porzeżyńska, Joanna Jadwiga, Fałek, Wojciech, Rajmund Jaguścik, Ptasińska, Karolina, Dominik Andrzej Walczak, Szymański, Bartosz, Monika Czerwińska, Kozaczek, Leokadia, Trzeciak, Piotr Wojciech, Joanna Jadwiga Porzeżyńska, Walczak, Dominik Andrzej, Wojciech Fałek, Piotr Wojciech Trzeciak, Jaguścik, Rajmund, Michał Wojtyniak, Leokadia Kozaczek, Karolina Ptasińska, Wojtyniak, Michał, Czerwińska, Monika   +19 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Feasibility of a disposable canister-free negative-pressure wound therapy (NPWT) device for treating open wounds in horses

BMC Veterinary Research, 2019
Background Wounds are among the most common medical conditions affecting horses and have a major economic impact on the horse industry. Wound healing in horses is distinct to that documented in other species, and often results in delayed healing and ...
Louis Kamus, Marie Rameau, Christine Theoret   +2 more
doaj   +1 more source

A simple and low- cost technique for Closed Incision Negative-Pressure Therapy [PDF]

, 2017
Surgical site infection (SSI) makes patient care more expensive by prolonging antibiotic usage and hospital stay. Negative pressure wound therapy (NPWT) has been recently reported as a preventive strategy to avoid SSI.
Michał Wojtyniak, Zbigniew Pasieka, Dominik Andrzej Walczak, Pawełczak, Dariusz, Wojtyniak, Michał, Trzeciak, Piotr Wojciech, Pasieka, Zbigniew, Dariusz Pawełczak, Walczak, Dominik Andrzej, Piotr Wojciech Trzeciak   +9 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Prospective Assessment of the Negative Pressure Wound Therapy of the Open Abdomen [PDF]

, 2016
Open abdomen (OA) is a surgical approach, that emerged in last 15 years, with its management being complicated, timely and financially demanding, burdened with high morbidity and mortality.
Hutan, Martin, Skultety, Jan, Sekac, Jaroslav, Kutarna, Juraj, Loncsar, Gerhard, Prochotsky, Augustin, Bartko, Christian   +6 more
core   +1 more source

Comparison of Negative Pressure Wound Therapy Versus Conventional Wound Care in the Treatment of Mesh Infection Following Incisional Hernia Repair

Medicine Science
Postoperative incisional hernias are common complications following abdominal surgeries, necessitating timely repair to mitigate the risk of incarceration.
Husnu Cagri Genc, Hakki Coskun
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source