Results 81 to 90 of about 5,785,757 (269)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Quantifying the distinct role of plasmon enhancement mechanisms in prototypical antenna-reactor photocatalysts

Nature Communications
Plasmonic photocatalysis enabled by the unique localized surface plasmon resonance represents a promising approach for efficient solar energy conversion.
Shuang Liu, Zhiyi Wu, Zhijie Zhu, Kai Feng, Yuxuan Zhou, Xinge Hu, Xiong Huang, Binbin Zhang, Xudong Dong, Yueru Ma, Kaiqi Nie, Jiahui Shen, Zidi Wang, Jiari He, Jiaqi Wang, Yu Ji, Binhang Yan, Qingfeng Zhang, Alexander Genest, Xiaohong Zhang, Chaoran Li, Bo Wu, Xingda An, Günther Rupprechter, Le He   +24 more
doaj   +1 more source

Highly Suspected COVID-19 Cluster with Multiple Negative SARS-CoV-2 RNA Tests: A Case Report

Infection and Drug Resistance, 2021
Xialing Huang,1 Xiaoping Long,2 Jun Zi,3 Ping Liu4 1Department of Infectious Diseases, Leiyang People’s Hospital, Leiyang, Hunan, 421800, People’s Republic of China; 2Pulmonary and Critical Care Medicine, The First Affiliated Hospital of University of ...
Huang X, Long X, Zi J, Liu P
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structural types of sentences in Kosovo police communication centers

Comparative Legilinguistics
In this paper it will be analyzed grammatical and dialectal aspect of structural sentences of Albanian language used in six Kosovo Police Communication Centers.
Shemsi Haziri, Senad Neziri
doaj   +1 more source

Negative Theory

, 2019
The work is solved in the context of the origin of the universe and matter. I build on a modified version of the vacuum energy that I use to formulate the whole theory. This work addresses the increasingly important matter of matter in space. The aim of this work is to modify the theory of the origin of the universe and to show how all matter in the ...
openaire   +1 more source