Results 111 to 120 of about 9,958,990 (309)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Necros, Negative Approach and Meatmen concert flier, Freezer Theatre, Detroit, MI, April 3, 1982
, 1982 2015 photocopy from back of letter dated April 19, 1982 sent to Sharon Cheslow by Barry Henssler of a flier published in the "Smegma Journal" fanzine.
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The negative existential cycle in Bantu
, 2022 Renewal of negation has received ample study in Bantu languages. Still, the relevant literature does not mention a cross-linguistically recurrent source of standard negation, i.e., the existential negator.
Devos, MaudLW2180200115676092324714-0C13-11E2-AA3C-3DCD10BDE39D +2 more
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Interrelationships between negative mood and clinical constructs: a motivational systems approach. [PDF]
, 2014 A series of three experiments was designed to test predictions from a motivational systems approach to understanding the role of clinical constructs in anxiety-based problems.
Graham C L Davey +7 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Improvement of Therapy Outcomes after Negative Pressure Wound Therapy in a Patient with Acne inversa. [PDF]
, 2014 Treatment of acne inversa (also known as hidradenitis suppurativa) is complicated and chronic. This debilitating, inflammatory disease of the follicular sacks affects mostly young adults and has a strong negative impact on their quality of life.
Francuzik, Wojciech +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Licensing german negative polarity items in LTAG [PDF]
, 2008 Our paper aims at capturing the distribution of negative polarity items (NPIs) within lexicalized Tree Adjoining Grammar (LTAG). The condition under which an NPI can occur in a sentence is for it to be in the scope of a negation with no quantifiers ...
Lichte, Timm, Kallmeyer, Laura
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source