Results 241 to 250 of about 9,553,504 (308)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Who regulates when told? A systematic investigation of implicit to explicit emotion regulation. [PDF]

Front Psychol
Richmond JR, Nylocks KM, Coifman KG.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Individual differences in emotional reactivity: A multidimensional systematic review across the big five. [PDF]

PLoS One
Nguyen DN, Trinh CLP, Phan SVL, Pham OTY, Nguyen NTT.   +4 more
europepmc   +1 more source

High-Risk Rhabdomyosarcomas Feature a Convergent Cell State. [PDF]

Cancer Res
Whitfield HJ, Anderson ND, Burke C, Groot Koerkamp MJ, Parks C, Ogbonnah T, Wood Y, Piapi A, Robertson E, Watt E, White A, De Noon S, Kennedy J, Nagrecha R, Meister MT, Aladowicz E, Man YKS, Laspidea V, Trinh MK, Hodder A, Porter T, Lawrence JE, Tuck E, Nguyen T, Kelsey A, Flanagan AM, Hewitt R, Smeulders N, Slater O, Hutchinson JC, Sebire N, Shipley JM, Drost J, Straathof K, Behjati S.   +34 more
europepmc   +1 more source

Absence of Plasmodium falciparum Histidine-Rich Protein 2 and 3 (Pfhrp2/3) Gene Deletions in Rizal, Palawan, the Philippines. [PDF]

Am J Trop Med Hyg
Luchavez JS, Bareng APN, Spencer F, Thorburn SG, Macalinao MLM, Espino FEJ, Drakeley CJ, Hafalla JCR, Grignard L.   +8 more
europepmc   +1 more source

Longitudinal association between negative life events and depression among Chinese senior high school students: the mediating role of psychological inflexibility and the moderating role of meaning in life. [PDF]

Front Public Health
Wan Z, Cao M, Fang S, Yang S, Zhang X.
europepmc   +1 more source