Results 181 to 190 of about 14,118,684 (408)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Negative campaigning and affective polarization

open access: yes
This chapter takes stock of recent literature on negative campaigning and the potential driving role it plays in fostering affective polarization. We first discuss the link between polarization and negative campaigning in general terms, and argues that the former can be a structural driver of the latter.
Alessandro Nai, Elizabeth L. Young
openaire   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

The neuroinflammatory component of negative affect in patients with chronic pain

open access: yesMolecular Psychiatry, 2019
D. Albrecht   +14 more
semanticscholar   +1 more source

Why negative affectivity should not be controlled in job stress research: don't throw out the baby with the bath water

open access: bronze, 2000
Paul E. Spector   +3 more
openalex   +1 more source

Home - About - Disclaimer - Privacy