Results 101 to 110 of about 49,117 (256)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
On Affect: Function and Phenomenology [PDF]
, 2018 This paper explores the nature of emotions by considering what appear to be two differing, perhaps even conflicting, approaches to affectivity—an evolutionary functional account, on the one hand, and a phenomenological view, on the other.
Elpidorou, Andreas
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Implicit affectivity in clinically depressed patients during acute illness and recovery
BMC Psychiatry, 2019 Background Clinical depression is characterized by high levels of negative affect (NA) and attenuated positive affect (PA). Psychological and pharmacological treatments have been shown to reduce NA and to enhance PA in depressed patients.
Thomas Suslow +4 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
A experiência subjetiva da vida diária de pessoas com diagnóstico de esquizofrenia e sua relação com bem-estar psicológico e satisfação com a vida [PDF]
, 2012 Dissertação de mestrado integrado em Psicologia (área de especialização em Psicologia Clínica)Procurou-se, neste estudo, definir o conceito de esquizofrenia e emoções, integrando-se várias perspetivas e conceções dos autores mais conceituados para estas
Couto, Fábia Filipa Martins Costelha de Sousa
core
Schizophrenia and the Scaffolded Self [PDF]
, 2020 A family of recent externalist approaches in philosophy of mind argues that our psychological capacities are synchronically and diachronically “scaffolded” by external resources.
Krueger, Joel
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Gender differences in influences of temperament on olfactory reactivity and awareness
Scientific Reports, 2017 Children’s olfactory performance is associated with temperament but whether there is a link with olfactory reactivity and awareness is not known. In adults negative affectivity is linked to reactivity to environmental odours but it is not clear whether ...
Lenka Martinec Nováková +2 more
doaj +1 more source