Results 161 to 170 of about 9,515,284 (337)
Negative Affectivity Moderates the Relationship between Attentional Control and Focused Skin Picking. [PDF]
Int J Environ Res Public Health, 2022 Prochwicz K +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Reviewing the Effect of English as a Foreign Language Teachers' Positive and Negative Affectivity on Their Work Engagement. [PDF]
Front Psychol, 2022 Fan Y.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Is maternal negative affectivity related to psychosocial behavior of preterm and term-born toddlers through mother-child interaction? [PDF]
Front Psychol, 2022 Krijnen LJG, Verhoeven M, van Baar AL.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Vanderbilt BABIES Infant Func Conn & Negative Affectivity
Peer-reviewed article examining concurrent and prospective associations between DMN and FPN functional network connectivity and negative affectivity in ...
Sanjana Ravi +2 more
core
, 2017 There is uncertainty as to how heart rate variability (HRV), an index of flexible physiological reactivity, relates to an individual’s tendency to experience negative emotions. Research suggests that high and low HRV may reflect maladaptive physiological
Gray, Jackson M.
core
The role of optimism and gratitude in the link between negative affectivity and suicide risk (viz., depressive symptoms and suicidal ideation) was examined in a sample of 1401 Spanish adolescents.
Extremera, Natalio +4 more
core +1 more source