Results 181 to 190 of about 9,515,284 (337)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mediating Role of Negative Affectivity in the Association Between Lifetime Trauma and Gastrointestinal Symptoms. [PDF]

Healthcare (Basel)
Nass BYS, Dibbets P, Markus CR.
europepmc   +1 more source

How Supportive Ethical Relationships Are Negatively Related to Palliative Care Professionals' Negative Affectivity and Moral Distress: A Portuguese Sample. [PDF]

Int J Environ Res Public Health, 2022
Rego F, Sommovigo V, Setti I, Giardini A, Alves E, Morgado J, Maffoni M.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Exploring links between sensory processing sensitivity, professional quality of life, and negative affectivity in clinical and counselling psychologists. [PDF]

PLOS Ment Health
McQuarrie AM, Jakobson LS.
europepmc   +1 more source

Perception of infant sleep problems: the role of negative affectivity and maternal depression. [PDF]

J Clin Sleep Med, 2021
Burdayron R, Butler BP, Béliveau MJ, Dubois-Comtois K, Pennestri MH.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preconception maternal posttraumatic stress and child negative affectivity: Prospectively evaluating the intergenerational impact of trauma. [PDF]

Dev Psychopathol, 2023
Swales DA, Davis EP, Mahrer NE, Guardino CM, Shalowitz MU, Ramey SL, Dunkel Schetter C.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Analysis of the Relation between University Students' Life Positions and their Positive-Negative Affectivity

, 2013
This study aims at comparing relation between life positions and positive-negative affectivity of university students in Turkey. 271 university students participated in the study; 147 of these students were female while 124 of them were male.
Ä°ÅžGÖR, Ä°sa Yücel; Department of Educatıonal Scıences, Psychological Counseling and Guidance, Erzincan University, AKBABA, Sırrı; Department of Educatıonal Scıences, Psychological Counseling and Guidance, Bursa University, ÖZPOLAT, Ahmet Ragıp; Department of Educatıonal Scıences, Psychological Counseling and Guidance, Erzincan University   +2 more
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