Results 31 to 40 of about 110,813 (305)

Differential expression analysis for sequence count data

, 2010
*Motivation:* High-throughput nucleotide sequencing provides quantitative readouts in assays for RNA expression (RNA-Seq), protein-DNA binding (ChIP-Seq) or cell counting (barcode sequencing).
Simon Anders, Wolfgang Huber, Klawonn, Frank   +2 more
core   +1 more source

Estimation for the bivariate negative binomial distribution

Journal of Statistical Computation and Simulation, 1985
Subrahmaniam and Subrahmaniam (1973) have considered several estimation procedures for the parameters of the bivariate negative binomial distribution. In this paper even-point estimators are examined and relative comparisons with maximum likelihood, moment and zero-zero cell frequency estimators are given.
Loukas, S., Papageorgiou, H.
openaire   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Goodness-of-Fit Test for the Bivariate Negative Binomial Distribution

Axioms
When modeling real-world data, we face the challenge of determining which probability distribution best represents the data. To address this intricate problem, we rely on goodness-of-fit tests.
Francisco Novoa-Muñoz, Juan Pablo Aguirre-González   +1 more
doaj   +1 more source

Asymptotic inversion of the binomial and negative binomial cumulative distribution functions [PDF]

ETNA - Electronic Transactions on Numerical Analysis, 2020
The computation and inversion of the binomial and negative binomial cumulative distribution functions play a key role in many applications. In this paper, we explain how methods used for the central beta distribution function (described in [2]) can be used to obtain asymptotic representations of these functions, and also for their inversion.
A. Gil (Amparo), J. Segura (Javier), N.M. Temme (Nico)   +2 more
openaire   +3 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

New bounds on Poisson approximation to the distribution of a sum of negative binomial random variables [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2018
The Stein-Chen method is usedto give new bounds, non-uniform bounds, for the distances between the distribution of a sum of independent negative binomial random variables and a Poisson distribution with mean, where ri and pi = 1-qi are parameters of ...
Kanint Teerapabolarn
doaj   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Inference on parameter β of the Generalized Negative Binomial Distribution

, 2022
In this paper, we propose a generalized likelihood ratio test to discernwhether a set of data fits a Negative Binomial as a particular case of theGeneralized Negative Binomial Distribution(GNBD).
Vaquera Huerta, Humberto; Colegio de Postgraduados
core   +1 more source