Results 91 to 100 of about 91,665 (284)
Negative sensitive items and the discourse-configurational nature of Japanese
Glossa, 2016 We take up three Negative Sensitive Items (NSIs) in Japanese, Wh-MO plain negative indefinites, exceptive XP-sika, and certain minimizing indefinites, such as rokuna N (‘any decent N’).
Hedde Zeijlstra +2 more
doaj +2 more sources
Fragment answers and double negation in strict negative concord languages [PDF]
, 2016 International audienceThis paper revisits the phenomenon of negative concord (NC) as an instance of polarity sensitivity. We shed light on a new set of data regarding n-words as fragment answers to negative questions and show that we find unexpected ...
Falaus, Anamaria, Nicolae, Andreea
core +5 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
The Augsburg Confession in Context (Part 1) [PDF]
, 1979 Lutherans cannot truly look forward into the 1980s without first looking back to the 1520s and 1530s — to the “confessional rocks” from which they were ...
Ritter, Walter A.
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Negative concord in Washo as negative agreement
Proceedings of the Linguistic Society of America, 2019 Washo, a Native American isolate, displays negative concord morphology in the context of negation. Negative concord in Washo comes in the form of the morpheme -Na, which may be suffixed onto optionally many sentential elements in a single clause. Given the apparent lack of semantic contribution by this morpheme, I argue - building on accounts along the
openaire +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Climate Change in the Piscataqua/Great Bay Region: Past, Present, and Future [PDF]
, 2011 Earth ’s climate changes. It always has and always will. However, an extensive body of scientific evidence indicates that human activities are now a significant force driving change in the Earth’s climate system.
Burakowski, Elizabeth +6 more
core +1 more source