Results 71 to 80 of about 3,656,879 (280)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Negative concord in Romanian as polyadic quantification [PDF]
, 2009 In this paper we develop an HPSG syntax-semantics of negative concord in Romanian. We show that n-words in Romanian can best be treated as negative quantifiers which may combine by resumption to form polyadic negative quantifiers.
Richter, Frank, Iordăchioaia, Gianina
core +1 more source
NJES: Nordic Journal of English studies, 2016 Intensification, a general device used by speakers to convey their message more clearly and to strengthen their position to it (Bolinger 1972), has been discussed widely in the literature.
Ignacio M. Palacios Martínez
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
THE FOCAL STRUCTURE IN MANDARIN VP-ELLIPSIS: A CROSS-LINGUISTIC PERSPECTIVE [PDF]
Taiwan Journal of Linguistics, 2009 This paper argues that Soh’s (2007) ΣP analysis only partially explains polarity operation in Mandarin VP-ellipsis. With new examples of the use of the particle que ‘however’, a polarity contrast of ye ‘also’, we propose that there are two focus ...
Ting-Chi Wei
doaj
Negative conjuncts and negative concord across the board
, 2021 Negative concord is a prominent one-to-many correspondence between form and meaning at the syntax-semantics interface, in which one semantic function may correlate with several semantic exponents. Languages are typically classified as showing negative concord or not, yet they all seem to exhibit the same interpretation strategy of conjoined negative ...
Sailer, Manfred, Richter, Frank
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source