Results 131 to 140 of about 1,088 (233)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Concordância negativa em português e a sue evolução
Études romanes de Brno, 2013 The Sentential negation, and the negative concord in particular, is a complex phenomenon which is far from being diachronically invariable. We could observe on the example of Portuguese that the main reason for the diachronic variation in the field of ...
Metoděj Polášek
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A closer look at Negative Concord in Afrikaans
Stellenbosch Papers in Linguistics Plus, 2007 Biberauer, Theresa
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Negative concord and TAM: a new perspective
It has been proposed in the syntactic literature on Negative Concord(NC) that Negative Concord Item(s) (NCIs) move to a particular position in syntax,i.e. SpecNegP (Haegeman 1995, Zanuttini 1997), to give rise to concord. SpecNegPis also the position for (some) Standard Negators (SN).
openaire +2 more sources
The negative concord illusion: An acceptability study with Czech neg-words
Linguistics VanguardLanguages such as Czech exhibit negative concord} a requirement for any neg-word (e.g. 'nobody') in a clause to be accompanied by sentential negation. Theoretical treatments see it as either a case of syntactic agreement or subsume it under NPI licensing. Interestingly, in the processing of both agreement and NPIs, the inclusion of a distractor element
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source