Results 61 to 70 of about 7,354,206 (251)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A technique for analysis of density dependence in population models
, 2018 The concept of density-dependent population growth is fundamental to our understanding of how populations persist. While it is generally agreed that negative density dependence must occur at high densities, the direction of density dependence may be ...
Piiroinen, Petri T. +3 more
core +1 more source
Spatially heterogeneous populations with mixed negative and positive local density dependence [PDF]
, 2016 Identifying the steady states of a population is a key issue in theoretical ecology, that includes the study of spatially heterogeneous populations. There are several examples of real ecosystems in patchy environments where the habitats are heterogeneous
Knipl, D +3 more
core +1 more source
Detection of delayed density dependence in an orchid population
, 2000 1 Annual censuses of Orchis morio (green-winged orchid) flowering spikes have been taken over a 27-year period in a replicated factorial experiment on the effects of fertilizer application.
Gillman, M. P., Dodd, M.
core +4 more sources
Density Dependence and Adult Survival Drive Dynamics in Two High Elevation Amphibian Populations
Diversity, 2020 Amphibian conservation has progressed from the identification of declines to mitigation, but efforts are hampered by the lack of nuanced information about the effects of environmental characteristics and stressors on mechanistic processes of population ...
Amanda M. Kissel +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2023 Applications of ecological theory to natural communities often assume that competitive, negative density-dependent processes are the only type of interaction important for diversity maintenance.
Mayfield, Margaret +2 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Ecology and Evolution, 2022 Density dependence in reproduction plays an important role in stabilizing population dynamics via immediate negative feedback from population density to reproductive output.
Guozhen Shang +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source