Results 121 to 130 of about 4,049,770 (316)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2015 Clinical experience and basic science studies show that Negative Pressure Wound Therapy (NPWT) is a promising yet still under-used treatment method for patients with diabetic foot syndrome (DFS).
Mrozikiewicz-Rakowska, Beata +5 more
core +1 more source
The dark side of social relationships – the context of the video game industry
International Journal of Management and EconomicsThe paper aims to explore the negative impacts of social relationships (SR) on business activity. As a research context, the video game industry (VGI) and the video game developers’ (VGDs) relationships are analyzed.
Czernek-Marszałek Katarzyna +2 more
doaj +1 more source
مجلة كلية التربية للبناتThe current research aims to identify the positive and negative effects of technology on the cognitive development of children from the point of view of their teachers, and to identify statistically significant differences in the positive and negative ...
Safa Tairq Habeeb +1 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Possible Negative Effects of Psychotherapies [PDF]
Psikiyatride Güncel Yaklaşımlar, 2012 Any treatment that has the potential to be useful could also have harmful effects on patients. All psychotherapy approaches should take this issue into consideration. Although there is no direct intervention to the physical integrity of the patient, this
I. Volkan Gulum
doaj
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Negative variance estimates in panel data models [PDF]
Negative values for estimated variances can arise in a panel data context. Empirical and theoretical literature dismisses the problem as not serious and a practical solution is to replace negative variances by its boundary value, i.e. zero. While this is
Laura Magazzini, Giorgio Calzolari
core
Perish in gossip? Nonlinear effects of perceived negative workplace gossip on job performance
, 2019 Purpose The purpose of this paper is to investigate the curvilinear relationship between perceived negative workplace gossip and target employee’s task performance, and the moderating roles of perceived organizational support (POS).Design/methodology ...
core +1 more source