Results 111 to 120 of about 4,049,770 (316)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2012 To date no research has examined the effects of negative state on the perception of everyday injury risk. Instead, studies have focussed more broadly on the relationship between mood and self- reported optimism. The present study had two aims.
Morgan, J, Garthwaite, J
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Negative Effects of Brand Extension
JISR Management and Social Sciences & Economics, 2010 Academicians in general, and students in particular, have recently started idealizing and romanticizing hypotheses-based empirical studies, so much so, that they incorporate hypotheses in their reports and papers, whether there is any need for them or ...
Tariq Jalees, Nadia Tariq
doaj +1 more source
Negative Effects of Addiction [PDF]
Pharmaceutical Regulatory Affairs: Open Access, 2012 Addiction is a condition that results when a person ingests or continues using a substance which leads to changing of the mood or behavior. These days the term of addiction does not include addiction to substances such as alcohol or cocaine or nicotine but it has expands to include addiction to computer, video games, exercise abuse, pornography and ...
openaire +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Editorial: Unsuccessful Psychotherapies: When and How Do Treatments Fail?
Frontiers in Psychology, 2020 Osmano Oasi, Andrzej Werbart
doaj +1 more source
Welfare: The Negative Societal Effects
Acta Economica et Turistica, 2015 The welfare system was instituted, presumably, to decrease poverty, increase the wealth and well-being of the poor. Paradoxically, it has had just about the opposite effect. How did this boomerang in public policy occur? It is simple.
Knight Victoria +2 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Evidence on public health interventions to prevent the negative health effects of climate change [PDF]
Suggested Citation: Anderson H, Brown C, Cameron LL, Christenson M, Conlon KC, Dorevitch S, Dumas J, Eidson M, Ferguson A, Grossman E, Hanson A, Hess JJ, Hoppe B, Horton J, Jagger M, Krueger S, Largo TW, Losurdo GM, Mack SR, Moran C, Mutnansky C, Raab K,
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