Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger +5 more
wiley +1 more source
Identification of surface defects and <i>in situ</i> lattice reconstruction of upconversion nanoparticles. [PDF]
Wang F +9 more
europepmc +1 more source
Spatially distributing Ti3C2Tx nanosheets into core‐shell architecture, rather than as directly dispersed flakes, mitigates aggregation and enhances photon harvesting. When the Ti3C2Tx core‐shell particles are incorporated into a shape‐memory polymer matrix at an ultralow loading of 0.0024 wt%, the improved photothermal conversion translates into ...
May Maung Zaw +12 more
wiley +1 more source
Direction-specific biomarker profiles and clinical significance of plasma p-tau217/amyloid PET discordance in cognitively normal adults. [PDF]
Huang Y +7 more
europepmc +1 more source
This study introduces selenium‐integrated cyanine dye (Se‐Cyn), with superior photostability, absorption, and photothermal efficiency, outperforming ICG in NIR window. Its nanoparticle form remains stable in water, accumulates in tumors, and enables strong optoacoustic imaging and effective phototherapy outcomes.
Divyesh Shelar +11 more
wiley +1 more source
Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression. [PDF]
Lan G +41 more
europepmc +1 more source
Material Coupling in Hybrid Neuromorphic Devices: From Fundamentals to System‐Level Applications
Hybrid neuromorphic devices utilize heterointerfaces between emerging semiconductors, where charge transfer and trapping, ion or defect modulation, and photogating are translated into synaptic functions. This paper discusses coupling strategies that tailor interfacial electronic and ionic properties in organic semiconductors, metal oxides, two ...
Minsu So +5 more
wiley +1 more source
Fluoropolymers across Their Life Cycle: Why "Emissions Reduction" Is Not "Safe". [PDF]
Figuière R +8 more
europepmc +1 more source
A particle‐level dual‐polymer interphase of carboxymethyl cellulose (CMC) and poly(acrylic acid) (PAA) stabilizes zinc metal powder anodes by coupling CMC‐mediated water regulation with PAA‐derived Zn2+ affinity. This synergy suppresses hydrogen evolution, corrosion, and byproduct accumulation while preserving electrode‐level electrical contact ...
Yunah Ahn +7 more
wiley +1 more source
A study on the nonlinear impact and mechanism of artificial intelligence application level on corporate carbon emission intensity. [PDF]
Yuan S, Zhang L, Liu W, Yang B.
europepmc +1 more source

