Results 131 to 140 of about 6,536,054 (294)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
, 2004 BACKGROUND: Available treatments for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B are associated with poor sustained responses. As a result, nucleoside and nucleotide analogues are typically continued indefinitely, a strategy ...
PEGINTERFERON ALFA A. HBEAG NEGATIVE CHRONIC HEPATITIS B. STUDY GROUP +3 more
core
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Interview with Lorna Wánosts’a7 Williams in Gamla
, 1993 Production material centres around a short interview conducted with Lorna Wánosts’a7 Williams in the ruins of Gamla, located in the Golan Heights region. In tape 1, Wánosts’a7 reflects on the site’s layers of history and compares it to how the layers of
Face to Face Media
core +1 more source
The impact of awareness on affective emoji priming in visual word recognition
Scientific ReportsEmojis have become integral to digital communication, yet their impact on downstream cognitive processing is not fully understood. In two lexical decision experiments, we examined the behavioral and electrophysiological effects of emoji primes that ...
Demian Stoianov +4 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Interview with Lorna Wánosts’a7 Williams at s7ístken site
, 1993 Production material centres around two interviews conducted with Lorna Wánosts’a7 Williams near the former site of a S7ístken, a traditional semi-subterranean winter dwelling of the Lil̓wat7úl, along the Birkenhead River.
Face to Face Media
core +1 more source
, 1993 Content warning: Tape VR63 contains a brief description of a racist encounter targeting an African American woman in which highly offensive language is used.
Face to Face Media
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source