Results 41 to 50 of about 8,875 (259)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Syntactic variation and diglossia in French [PDF]
, 2011 The present article addresses syntactic variation within French, and is an example of a relatively recent shift in attitude towards variation in this language.
Rowlett, PA
core
The Pragmatics of Arabic Religious Posts on Facebook: A Relevance-Theoretic Account [PDF]
, 2017 Despite growing interest in the impact of computer-mediated communication on our lives, linguistic studies on such communication conducted in the Arabic language are scarce.
Zaki, Mai
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Studies in Engineering EducationBackground: Research on the ways that students’ interactions in collaborative, project-based learning has described how important learning opportunities, such as opportunities to contribute, implement, and refine ideas, must be negotiated amongst ...
Trevion Shamir Henderson
doaj +1 more source
Managing the Moral Implications of Advice in Informal Interaction [PDF]
, 2013 What does advice giving look like among family members? Most conversation analytic research on advice has been in institutional settings, which constrain what speakers can do.
Hepburn, A, Shaw, C
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Individuated Embodiment and Action: Interrogating Roberto Esposito’s Negative Self
Mosaic: a journal for the interdisciplinary study of literature, 2015 This essay argues that the resistance of the negative self to politicization that Roberto Esposito posits requires a more robust account for the facticity of individual embodiment and agency, which ultimately challenge the originary space that characterize Esposito’s claims about possible sites of resistance.
openaire +2 more sources