Results 91 to 100 of about 333,485 (307)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The extraction of negative carbon ions from a volume cusp ion source [PDF]

, 2017
Acetylene and carbon dioxide gases are used in a filament-powered volume-cusp ion source to produce negative carbon ions for the purpose of carbon implantation for gettering applications.
Hamish McDonald, McDonald, Hamish, Tobin Jones, Jeff Martin, Dave Potkins, Kalvas, Taneli, Olli Tarvainen, Philpott, Chris, Joseph Theroux, Hollinger, Craig, Theroux, Joseph, Stephane Melanson, Craig Hollinger, Jones, Tobin, Tarvainen, Olli, Potkins, Dave, Melanson, Stephane, Morgan Dehnel, Taneli Kalvas, Thomas Stewart, Stewart, Thomas, Dehnel, Morgan, Chris Philpott, Philip Jackle, Martin, Jeff, Jackle, Philip   +25 more
core   +1 more source

Simulations for the cesium dynamics of the RF-driven prototype ion source for CRAFT N-NBI

Nuclear Engineering and Technology
To realize an initial objective of the negative ion-based neutral beam injection (N-NBI) at the Comprehensive Research Facility for Fusion Technology (CRAFT) test facility, which targets an H0 beam power of 2 MW at an energy of 200–400 keV and a pulse ...
Yalong Yang, Yong Wu, Lizhen Liang, Jianglong Wei, Rui Zhang, Yahong Xie, Wei Liu, Chundong Hu   +7 more
doaj   +1 more source

Modeling of plasma transport and negative ion extraction in a magnetized radio-frequency plasma source

New Journal of Physics, 2017
Negative ion sources for fusion are high densities plasma sources in large discharge volumes. There are many challenges in the modeling of these sources, due to numerical constraints associated with the high plasma density, to the coupling between plasma
G Fubiani, L Garrigues, G Hagelaar, N Kohen, J P Boeuf   +4 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Assessment of plasma uniformity in the extraction region of an RF-driven negative ion source for CRAFT NNBI

Nuclear Fusion
The uniformity of beam, for large RF negative ion source, is closely related to the plasma uniformity in the extraction region. The six electrostatic probes were installed above the plasma grid (PG) 5 mm to evaluate the plasma uniformity.
Xufeng Peng, Yongjian Xu, Yufan Li, Jianglong Wei, Guangyong Mei, Bo Liu, YuWen Yang, Na Wang, Junwei Xie, Yahong Xie, Lizhen Liang, Bin Wu   +11 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Negative Ion Beam Focusing in a Plasma Sputter-type Negative Ion Source [PDF]

, 2007
The ion beam produced from a plasma sputter-type negative ion source with Zr target was analyzed, and the negative ion beam current was increased by focusing with an electrostatic Einzel lens.
Garcia, Alipio, Yambot, Miguel, Mendenilla, Alexander, Ramos, Henry, Valmoria, Nico   +4 more
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source