Results 41 to 50 of about 1,126,427 (279)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A Simple Electrostatic Device for Eliminating Tobacco Sidestream Smoke to Prevent Passive Smoking

Instruments, 2018
An electrostatic apparatus was constructed to capture tobacco sidestream smoke. This apparatus consisted of a perforated polypropylene plate with metal spikes and a grounded metal net arrayed in parallel at a defined interval.
Yoshinori Matsuda, Koji Kakutani, Teruo Nonomura, Yoshihiro Takikawa, Kiyotsugu Okada, Manabu Shibao, Kazuhiro Miyama, Shinya Yokoo, Shin-ichi Kusakari, Hideyoshi Toyoda   +9 more
doaj   +1 more source

Criticality in confined ionic fluids

, 2001
A theory of a confined two dimensional electrolyte is presented. The positive and negative ions, interacting by a $1/r$ potential, are constrained to move on an interface separating two solvents with dielectric constants $\epsilon_1$ and $\epsilon_2$. It
A.Z. Panagiotopoulos, D.A. McQuarrie, E.S. Velazquez, E.Z. Güntelberg, G. Orkoulas, H. Weingärtner, I.S. Jacobs, J. E. Flores-Mena, J. Valleau, J.-M. Caillol, J.C. Shelley, J.J. Weis, J.J. Weis, J.M. Cailol, J.M. Cailol, J.P. Valleau, M.E. Fisher, M.E. Fisher, M.E. van Leeuwen, M.J. Stevens, Marcia C. Barbosa, N. Bjerrum, P. Pincus, P.J. Camp, P.W. Debye, Q. Yan, R.A. Salkar, R.P. Sear, R.R. Singh, T. Narayanan, T. Tlusty, W. Ebeling, W. Schröer, Y. Levin, Y. Levin, Y. Levin, Yan Levin   +36 more
core   +1 more source

Trace ions rejection tunning in NF by selecting solution composition: Ion permeances estimation [PDF]

, 2017
Nanofiltration (NF) is suggested to selectively remove ionic species in aqueous process streams taking benefit of both membrane and aqueous solution composition. The importance of predicting and optimizing selective ion rejections by NF not only of major
Cortina Pallás, José Luís, Gibert Agulló, Oriol, Pagès Hernando, Neus, Reig i Amat, Mònica   +3 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Exposure of laboratory animals to small air ions: a systematic review of biological and behavioral studies

BioMedical Engineering OnLine, 2018
Background Air ions are molecules of air that have become ionized—that is, they have either lost or gained an electrical charge. Past speculation has suggested that exposure to positive air ions may be harmful to one’s health, while exposure to negative ...
William H. Bailey, Amy Lavin Williams, Megan Jeanne Leonhard   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Combating the 'Sick Building Syndrome' by Improving Indoor Air Quality

Construction Economics and Building, 2012
Research indicates that many of symptoms attributed to the Sick Building Syndrome in air-conditioned office buildings are a result of considerably reduced negative ions in the internal atmosphere and that replacing the depleted negative ions can improve ...
Pongchai Nimcharoenwon, Graham Miller
doaj   +3 more sources