Results 61 to 70 of about 437,401 (314)

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]

, 2013
The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
A Merla, B Onken, C Banning, C Vanni, Cathryn Weston, DA Hughes, EC Chang, FD Kelly, FO Bendezú, FS Wouters, G Ladds, G Ladds, G Ladds, G Ladds, G Ladds, G Ladds, Graham Ladds, H Murakoshi, H Tatebe, H Tu, I Tratner, J Davey, J Davey, J Davey, J Marks, JL Brown, JM Mitchison, Juan Mata, K Hirota, K Kitamura, K Maundrell, K Nakano, K Scheffzek, M Das, M Didmon, M Hachet-Haas, M Hamilton, M Malumbres, M Toya, MD Abramoff, Michael Bond, O Nielsen, P Fantes, P García, P Gideon, P Papadaki, PM Coll, R Egel, S Ottilie, S Sazer, SA Rincón, SR Sprang, T Masuda, TT Maeda, V Jung, V Snell, Wayne Croft, Y Imai, Y Imai   +58 more
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Licensing german negative polarity items in LTAG [PDF]

, 2008
Our paper aims at capturing the distribution of negative polarity items (NPIs) within lexicalized Tree Adjoining Grammar (LTAG). The condition under which an NPI can occur in a sentence is for it to be in the scope of a negation with no quantifiers ...
Kallmeyer, Laura, Lichte, Timm
core  

Parasitic licensing of negative polarity items [PDF]

The Journal of Comparative Germanic Linguistics, 2007
This paper proposes a new treatment of parasitically licensed negative polarity items, based on the idea that indefinite negative polarity items may optionally incorporate a negative feature from their licenser, and thus acquire the necessary features to in turn license a negative polarity item.
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Impulsive Flashover Characteristics and Weibull Statistical Analysis of Gas-Solid Interfaces With Varying Relative Humidity

IEEE Access, 2020
This paper informs on the flashover strength of three materials: Delrin (polyoxymethylene), HDPE (high-density polyethylene) and Ultem (polyetherimide) with smooth surface finishes, in zero-grade air at -0.5, 0 and 0.5 bar gauge, and at <; 10%, ~50 ...
Ruairidh W. Macpherson, Mark P. Wilson, Igor V. Timoshkin, Scott J. Macgregor, Martin J. Given   +4 more
doaj   +1 more source

Polarization-filtering and polarization-maintaining low-loss negative curvature fibers

Optics Express, 2018
We propose a polarization-filtering and polarization-maintaining negative curvature fiber in which two nested resonant tubes are added to a standard negative curvature fiber with one ring of tubes. The coupling between the glass modes in the nested resonant tubes and the fundamental core modes is used to increase the birefringence and differential loss
Chengli Wei, Curtis R. Menyuk, Jonathan Hu   +2 more
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Deep Memory Networks for Attitude Identification

, 2017
We consider the task of identifying attitudes towards a given set of entities from text. Conventionally, this task is decomposed into two separate subtasks: target detection that identifies whether each entity is mentioned in the text, either explicitly ...
Chang C.-C., Collobert R., De Marneffe M.-C., Faulkner A., Gimpel K., Glorot X., Hasan K. S., Hermann K. M., Irsoy O., Jiang L., Kingma D., Kobayashi N., Le Q. V., Li F., Mikolov T., Mohammad S. M., Popescu A., Socher R., Socher R., Sukhbaatar S., Vo D.-T., Walker M. A., Wang S., Zhang M., Zirn C.   +24 more
core   +1 more source