Results 71 to 80 of about 437,401 (314)
Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae [PDF]
, 2009 This article is available open access through the publisher’s website at the link below. Copyright @ 2009 The Authors.The conserved Rho-type GTPase Cdc42p is a key regulator of signal transduction and polarity in eukaryotic cells.
Daum, G +4 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Building Phrase Polarity Lexicons for Sentiment Analysis
International Journal of Interactive Multimedia and Artificial Intelligence, 2018 Many approaches to sentiment analysis benefit from polarity lexicons. Most polarity lexicons include a list of polar (positive/negative) words, and sentiment analysis systems attempt to capture the occurrence of those words in text using polarity ...
Rahim Dehkharghani
doaj +1 more source
Ignition and propagation of nanosecond pulsed plasmas in distilled water—Negative vs positive polarity applied to a pin electrode [PDF]
, 2021 K. Grosse, M. Falke, A. von Keudell
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Yes or no, or how to answer a negative question
Linguistica, 2016 This paper deals with answers to negative yes-no questions, focusing on data from Czech. It is shown that answering particles can express both positive and negative answers to negative questions, but that their choice is not free.
Hana Gruet-Skrabalova
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Experimental study of multi-bubble hydraulic efficiency of spark-generated bubbles
AIP Advances, 2022 We investigated the hydraulic efficiency of spark-generated bubbles under conditions of different discharge polarities and different electrode numbers.
L. C. Zhang +7 more
doaj +1 more source