Results 31 to 40 of about 5,948,394 (284)

Fragment answers with negative dependencies in Korean: a direct interpretation approach

open access: yesLinguistics
Fragment answers are nonsentential utterances quite pervasive in daily-life dialogues. This article focuses on fragment answers involving a negative dependency expression in Korean. The key question for the analysis of such a negative fragment expression
Kim Jong-Bok
doaj   +1 more source

Intervention effects in NPI licensing: A quantitative assessment of the scalar implicature explanation

open access: yesGlossa, 2018
This paper reports on five experiments investigating intervention effects in negative polarity item (NPI) licensing. Such intervention effects involve the unexpected ungrammaticality of sentences that contain an intervener, such as a universal quantifier,
Emmanuel Chemla, Lyn Tieu, Milica Denić
doaj   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Ainda tem solução: uma proposta semântica [PDF]

open access: yes, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-graduação em LinguísticaEsta dissertação se insere no estudo da semântica das línguas naturais, sob a vertente formalista de condições de ...
Gritti, Letícia Lemos
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

This Is the Way People Are Negative Anymore: Mapping Emotionally Negative Affect in Syntactically Positive Anymore Through Sentiment Analysis of Tweets

open access: yesLanguages
The adverb anymore is standardly a negative polarity item (NPI), which must be licensed by triggers of non-positive polarity. Some Englishes also allow anymore in positive-polarity clauses.
Christopher Strelluf, Thomas T. Hills
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

When Implicit Offence Is Not Necessarily Negative: Pragmatic Strategies and Sentiment Polarity in Chinese Online Attacks

open access: yesApplied Sciences
This study investigates how sentiment polarity relates to offensive function in Chinese online attacks, focusing on cases where offence is expressed implicitly rather than through explicit negative wording.
Danyang Zheng, Shuangshuang Chen
doaj   +1 more source

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