Results 41 to 50 of about 57,391 (278)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The syntax of negative polarity items in Central Kurdish
Cogent Arts & HumanitiesThis paper investigates the morpho-syntactic properties and structure of hych kasek ‘anyone’ and hych shitek ‘anything’, two negative polarity items (NPIs) in Central Kurdish (CK).
Hussein Al-Bataineh +1 more
doaj +1 more source
The Effectiveness of Personalized Movie Explanations : An Experiment Using Commercial Meta-data [PDF]
, 2008 Preprin
Masthoff, Judith, Tintarev, Nava
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A register approach to negative concord versus negative polarity items in English
LinguisticsNegative concord (NC) is used in many English varieties but usually considered ungrammatical in ‘standard’ contemporary English, where negative polarity items (NPIs) are used.
Rotter Stephanie, Liu Mingya
doaj +1 more source
Frontiers in Psychology, 2019 This investigation draws from research on negative polarity item (NPI) illusions in order to explore a new and interesting instance of misalignment observed for grammatical sentences containing two negative markers.
Iria de-Dios-Flores, Iria de-Dios-Flores
doaj +1 more source
Journal of King Saud University: Computer and Information Sciences, 2021 The increase in the usage of internet and social media has enabled people exchange views, opinions and thoughts as never before. This exchange of data has paved the way for sentiment analysis.
J. Ramsingh, V. Bhuvaneswari
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source