Results 131 to 140 of about 743,467 (306)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The mean sensitivity, specificity, positive predictive value and negative predictive value of SCLIWC in single Weibo status scoring (N = 11).

, 2016
The mean sensitivity, specificity, positive predictive value and negative predictive value of SCLIWC in single Weibo status scoring (N = 11).
Dongdong Jiao (2847353), Nan Zhao (351674), Tingshao Zhu (512444), Shuotian Bai (2847350)   +3 more
core   +1 more source

The Paris System for reporting urinary cytology improves the negative predictive value of high-grade urothelial carcinoma. [PDF]

BMC Urol, 2022
Yamasaki M, Taoka R, Katakura K, Matsunaga T, Kani N, Honda T, Harada S, Tohi Y, Matsuoka Y, Kato T, Okazoe H, Tsunemori H, Ueda N, Haba R, Sugimoto M.   +14 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Screening test performance: estimated corrected positive predictive value and negative predictive values.

, 2013
CIN2+ = CIN2/CIN3/ICC, CIN3+ = CIN3/ICC, PPV = Positive predictive value, NPV = Negative predictive value, CI = Confidence interval, Cytology = Cytology Pap smear, HPV = HPV DNA, VIA = Visual inspection with 5% acetic acid.*Cytology negative: normal/LSIL/
Simon Levin (289528), Avril Swarts (289526), David A. Lewis (140277), Nomtha Mayisela (289523), Bruce Allan (289533), Sophie Williams (289525), Mark Faesen (289527), Pam Michelow (289529), Jennifer S. Smith (283828), Anna-Lise Williamson (50758), Cynthia Firnhaber (143741), Lu Mao (289524), Tanvier Omar (289531), Michael G. Hudgens (289532)   +13 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures

, 2011
Background: Current prognostic gene signatures for breast cancer mainly reflect proliferation status and have limited value in triple-negative (TNBC) cancers.
Pusztai, Lajos, Lajos Pusztai, Schmidt Marcus, Karn, Thomas, Lars Hanker, Holtrich Uwe, Ruckhäberle Eugen, Volkmar Müller, Liedtke, Cornelia, Karn Thomas, Shiang Christine Y., Rody Achim, Gätje, Regine, Solbach Christine, Eugen Ruckhäberle, Pusztai Lajos, Müller, Volkmar, Cornelia Liedtke, Rody, Achim, Ahr Andre, Ruckhäberle, Eugen, Marcus Schmidt, Christine Y Shiang, Solbach, Christine, Gaetje Regine, Ahr, André, Andre Ahr, Thomas Karn, Hanker Lars, Achim Rody, Schmidt, Marcus, Shiang, Christine Y., Hanker, Lars, Takayuki Iwamoto, Holtrich, Uwe, Iwamoto Takayuki, Manfred Kaufmann, Liedtke Cornelia, Uwe Holtrich, Christine Solbach, Müller Volkmar, Iwamoto, Takayuki, Kaufmann Manfred, Kaufmann, Manfred, Regine Gaetje   +44 more
core   +1 more source

The Negative Predictive Value of Harada Scoring for Coronary Artery Dilatation or Aneurysm in Children with Kawasaki Disease: A Cross-sectional Study. [PDF]

Iran J Med Sci, 2022
Malek A, Ghodsi A, Hamedi A.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Assessment of two researchers on the CLE images, including the average sensitivity, specificity, positive predictive value, negative predictive value and accuracy.

, 2014
Abbreviations: CLE, confocal laser endomicroscopy; PPV, positive predictive value; NPV, negative predictive value.Assessment of two researchers on the CLE images, including the average sensitivity, specificity, positive predictive value, negative ...
Lei Cui (165714), Yingsheng Cheng (625142), Minghua Li (277040), Biyuan Wang (625140), Hui Li (32376), Wenli Cui (625141), Yongdong Li (192610)   +6 more
core   +1 more source