Results 111 to 120 of about 743,467 (306)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Youden index of blood protozoan detection DNA microarrays.

, 2016
Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Youden index of blood protozoan detection DNA microarrays.
Xiao-Nong Zhou (92570), Xin-Yu Feng (3375101), Jia-Xu Chen (115580), Jun-Hu Chen (115591), Shao-Hong Chen (115595), Wei Hu (6560), Mu-Xin Chen (107152), Yu-Chun Cai (115603), Yan Lu (32611), Lin Ai (107138)   +9 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Sensitivity, specificity, positive predictive value, negative predictive value and analytic accuracy of IGRA in culture-positive or culture-negative TB patients.

, 2014
IGRA, interferon-gamma release assay; PPV, positive predicted value; NPV, negative predicted value; Acc, analytic accuracy; CI, confidence interval.Sensitivity, specificity, positive predictive value, negative predictive value and analytic accuracy of ...
Beata Janiszewska-Drobinska (629663), Marek Fol (261496), Grzegorz Kielnierowski (629664), Magdalena Kowalewicz-Kulbat (629665), Magdalena Druszczynska (629666), Marcin Wlodarczyk (629661), Wieslawa Rudnicka (629662)   +6 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sensitivity, specificity, positive predictive value, negative predictive value and analytic accuracy of TST in culture-positive or culture-negative TB patients.

, 2014
*TST induration cut-off 10 mm.TST, tuberculin skin test; PPV, positive predicted value; NPV, negative predicted value; Acc, analytic accuracy; CI, confidence interval.Sensitivity, specificity, positive predictive value, negative predictive value and ...
Beata Janiszewska-Drobinska (629663), Marek Fol (261496), Grzegorz Kielnierowski (629664), Magdalena Kowalewicz-Kulbat (629665), Magdalena Druszczynska (629666), Marcin Wlodarczyk (629661), Wieslawa Rudnicka (629662)   +6 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Sensitivity, specificity, positive predictive value, and negative predictive value of Model 1 and Model 2, by types of images used.

, 2019
Sensitivity, specificity, positive predictive value, and negative predictive value of Model 1 and Model 2, by types of images used.
Emile Redwood (7134905), Luis A. Marcos (6696991), Inès Vigan-Womas (58229), Simon Grandjean Lapierre (7252541), Ariel Yang (7134899), Liana Langdon-Embry (4670032), Nahid Bakhtari (7134902), Astrid M. Knoblauch (7134920), Armand Rafalimanantsoa (7134914), Juan De Dios Santos (7134917), Patricia Rakotomanga (7134911)   +10 more
core   +1 more source

Not All Patients Need a CT When the Appendix Is Not Seen on Ultrasound: A Scoping Review

Diagnostics
Background/Objective: Recent North American guidelines suggest that CT is indicated for further evaluation where ultrasound (US) is negative, although the negative predictive value (NPV) of ultrasound in adult patients when the appendix is not seen ...
Ali Ramji, Justin J. Y. Kim, Gavin Low, Karim Samji, Mitchell P. Wilson   +4 more
doaj   +1 more source