Results 151 to 160 of about 1,591,983 (307)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Diagnostic accuracy of pre-operative breast magnetic resonance imaging (MRI) in predicting axillary lymph node metastasis: variations in intrinsic subtypes, and strategy to improve negative predictive value-an analysis of 2473 invasive breast cancer patients. [PDF]

Breast Cancer, 2023
Chen ST, Lai HW, Chang JH, Liao CY, Wen TC, Wu WP, Wu HK, Lin YJ, Chang YJ, Chen ST, Chen DR, Huang HI, Hung CL.   +12 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Reducing the burden of surveillance in pregnant women with no history of fetal atrioventricular block using the negative predictive value of anti-Ro/SSA antibody titers. [PDF]

Am J Obstet Gynecol, 2022
Kaizer AM, Lindblade C, Clancy R, Tebo AE, Drewes B, Masson M, Chang M, Fraser N, Buyon JP, Cuneo BF.   +9 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions. [PDF]

Dermatol Res Pract, 2021
Seyed Ahadi M, Firooz A, Rahimi H, Jafari M, Tehranchinia Z.   +4 more
europepmc   +1 more source

Valor de la resonancia magnética en el diagnóstico de las lesiones de rodilla [PDF]

, 1996
Para determinar la eficacia diagnóstica de la resonancia magnética en las lesiones de la rodilla se han estudiado 60 pacientes tomando como referencia los hallazgos obtenidos en la artroscopia.
Bosch Reig, Vicente, López Casquero, C., Villanueva García, E.   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Negative predictive value of the FebriDx host response point-of-care test in patients presenting to a single Australian emergency department with suspected COVID-19: an observational diagnostic accuracy study. [PDF]

BMJ Open, 2022
Buntine P, Miller J, Pope A, Guy S, Wong FQA, McDonald H, Ahmed M, Teow KH, Roney M, Mohammadi F, Aldridge E, Hackett L, Jenner S, Davis B.   +13 more
europepmc   +1 more source

Comparison of Tan Thiam Hok, Ziehl Neelsen and Fluorochrome as Acid-Fast Bacilli Staining Methods in Sputum [PDF]

, 2005
Because of its simplicity, rapidity, low cost and relatively sensitive, sputum acid-fast bacilli (AFB) smear microscopy is the primary tool for detecting pulmonary tuberculosis and follow up of therapy. This experiment is aimed to determine the
Alisyahbana, B. (Bachti), Karuniawati, A. (Anis), Melia, W. (Wia), Nilawati, S. (S), Parwati, I. (Ida), Prawoto, P. (Prawoto), Risdiyani, E. (E), Rosana, Y. (Yeva), Sudiro, T. M. (T)   +8 more
core