Results 61 to 70 of about 2,876,710 (350)

Diagnostic testing in the context of high-value care: Incorporating prior probability [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2016
This is the fifth article of a series on fundamental concepts in biostatistics and research. In this article, the author reviews the fundamental concepts in diagnostic testing, prior probability and predictive value, and how they relate to the concept of
Lucien Cardinal
doaj   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Derivation of Generalized Equations for the Predictive Value of Sequential Screening Tests [PDF]

arXiv, 2020
Using Bayes' Theorem, we derive generalized equations to determine the positive and negative predictive value of screening tests undertaken sequentially. Where a is the sensitivity, b is the specificity, $\phi$ is the pre-test probability, the combined positive predictive value, $\rho(\phi)$, of $n$ serial positive tests, is described by: $\rho(\phi)
arxiv  

Capsule endoscopy: High negative predictive value in the long term despite a low diagnostic yield in patients with suspected Crohn's disease

United European Gastroenterology journal, 2013
Introduction The role of small bowel capsule endoscopy (SBCE) in Crohn's disease (CD) has expanded with greater understanding of the technology. The ability of SBCE to differentiate CD from other causes of inflammation has been questioned.
B. Hall, G. Holleran, D. Costigan, D. McNamara   +3 more
semanticscholar   +1 more source

Accuracy of ultrasonography in the evaluation of abdominal masses in children in Nigeria

African Journal of Paediatric Surgery, 2019
Introduction: Abdominal masses in children constitute a spectrum of lesions of diverse origin, nature and significance. In a low-income setting with limited investigative facilities, accurate diagnosis of abdominal masses can be very challenging. However,
Adebayo Ayokunle Adedayo, Joseph Bako Igashi, Philip Mari Mshelbwala, Abdulrashid A Nasir, Emmanuel A Ameh, James O Adeniran   +5 more
doaj   +1 more source

The new accounting for expected adjusted effect test (AEAE test) has higher positive predictive value than a zero-order significance test

BMC Research Notes, 2021
Objective The present simulation study aimed to assess positive predictive value (PPV) and negative predictive value (NPV) for our newly introduced Accounting for Expected Adjusted Effect test (AEAE test) and compare it to PPV and NPV for a traditional ...
Kimmo Sorjonen, Gustav Nilsonne, Bo Melin, Michael Ingre   +3 more
doaj   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Negative 4-Probe Conductances of Mesoscopic Superconducting Wires [PDF]

, 1994
We analyze the longitudinal 4-probe conductance of mesoscopic normal and superconducting wires and predict that in the superconducting case, large negative values can arise for both the weakly disordered and localized regimes. This contrasts sharply with the behaviour of the longitudinal 4-probe conductance of normal wires, which in the localized limit
arxiv   +1 more source

The role of endoscopic ultrasound-guided fine-needle aspiration/biopsy in the diagnosis of mediastinal lesions

Frontiers in Surgery, 2023
ObjectiveEndoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/FNB) is an accurate technique for sampling the pancreas and mediastinum. The aim of this study was to determine the value of EUS-FNA/FNB in the diagnosis of mediastinal lesions ...
Jingjing Zhou, Jingjing Zhou, Ting Cai, Ting Cai, Dongwen Wu, Dongwen Wu, Xiong Chen, Xiong Chen, Fen Wang, Fen Wang   +9 more
doaj   +1 more source